Methods involving long lasting synthetic exendin-4 peptide conjugates
First Claim
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1. A method for treating obesity in a subject, comprising administering to the subject a therapeutically effective amount of a compound according to the following formula:
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Abstract
Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
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32 Claims
- 1. A method for treating obesity in a subject, comprising administering to the subject a therapeutically effective amount of a compound according to the following formula:
- 3. A method for treating obesity in a subject, comprising administering to the subject a therapeutically effective amount of a conjugate formed by reacting a compound according to the following formula:
- 9. A method for treating decreased insulin sensitivity in a subject, comprising administering to the subject a therapeutically effective amount of a compound according to the following formula:
- 11. A method for treating decreased insulin sensitivity in a subject, comprising administering to the subject a therapeutically effective amount of a conjugate formed by reacting a compound according to the following formula:
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