Methods for treating hypercholesterolemia
First Claim
Patent Images
1. An antisense compound consisting of the nucleotide sequence selected from the group consisting of:
- SEQ ID NO;
65, SEQ ID NO;
188, SEQ ID NO;
60, SEQ ID NO;
381, SEQ ID NO;
212, SEQ ID NO;
62, SEQ ID NO;
288, SEQ ID NO;
180, and SEQ ID NO;
8.
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Accused Products
Abstract
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
109 Citations
68 Claims
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1. An antisense compound consisting of the nucleotide sequence selected from the group consisting of:
- SEQ ID NO;
65, SEQ ID NO;
188, SEQ ID NO;
60, SEQ ID NO;
381, SEQ ID NO;
212, SEQ ID NO;
62, SEQ ID NO;
288, SEQ ID NO;
180, and SEQ ID NO;
8. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- SEQ ID NO;
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15. A composition comprising an antisense compound consisting of the nucleotide sequence selected from the group consisting of:
- SEQ ID NO;
65, SEQ ID NO;
188, SEQ ID NO;
60, SEQ ID NO;
381, SEQ ID NO;
212, SEQ ID NO;
62, SEQ ID NO;
288, SEQ ID NO;
180, and SEQ ID NO;
8, and a pharmaceutically acceptable carrier or diluent. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
- SEQ ID NO;
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35. A method comprising administering to an animal an antisense compound consisting of the nucleotide sequence selected from the group consisting of:
- SEQ ID NO;
65, SEQ ID NO;
188, SEQ ID NO;
60, SEQ ID NO;
381, SEQ ID NO;
212, SEQ ID NO;
62, SEQ ID NO;
288, SEQ ID NO;
180, and SEQ ID NO;
8. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
- SEQ ID NO;
Specification