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Optimized Fc variants and methods for their generation

  • US 8,093,359 B2
  • Filed: 10/31/2007
  • Issued: 01/10/2012
  • Est. Priority Date: 09/27/2002
  • Status: Active Grant
First Claim
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1. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising amino acid substitutions 239D and 332E, wherein numbering is according to the EU index.

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