Optimized Fc variants and methods for their generation
First Claim
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1. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising amino acid substitutions 239D and 332E, wherein numbering is according to the EU index.
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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Citations
19 Claims
- 1. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising amino acid substitutions 239D and 332E, wherein numbering is according to the EU index.
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7. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising amino acid substitutions 239D and 332E, wherein said Fc variant increases binding affinity to an Fcγ
- R as compared to said parent Fc polypeptide and wherein numbering is according to the EU index.
- View Dependent Claims (8, 9, 10, 11, 12)
- 13. An antibody or immunoadhesin, wherein said antibody or immunoadhesin comprises amino acid substitutions 239D and 332E in the Fc region, wherein numbering is according to the EU index.
Specification