Tumor necrosis factor-gamma
First Claim
1. An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
- (a) a protein whose amino acid sequence consists of amino acid residues −
27 to 147 of SEQ ID NO;
2;
(b) a protein whose amino acid sequence consists of amino acid residues −
26 to 147 of SEQ ID NO;
2;
(c) a protein whose amino acid sequence consists of amino acid residues 1 to 147 of SEQ ID NO;
2;
(d) a protein whose amino acid sequence consists of amino acid residues 25 to 147 of SEQ ID NO;
2;
(e) a protein whose amino acid sequence consists of a portion of SEQ ID NO;
2, wherein said portion is at least 30 contiguous amino acid residues in length;
(f) a protein whose amino acid sequence consists of a portion of SEQ ID NO;
2, wherein said portion is at least 50 contiguous amino acid residues in length;
(g) a protein whose sequence consists of the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC™
Deposit Number 75927;
(h) a protein whose sequence consists of the amino acid sequence of the full-length polypeptide, excluding the N-terminal methionine residue, encoded by the cDNA contained in ATCC™
Deposit Number 75927; and
(i) a protein whose sequence consists of the amino acid sequence of the extracellular domain of the polypeptide encoded by the cDNA contained in ATCC™
Deposit Number 75927.
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Accused Products
Abstract
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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Citations
20 Claims
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1. An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
-
(a) a protein whose amino acid sequence consists of amino acid residues −
27 to 147 of SEQ ID NO;
2;(b) a protein whose amino acid sequence consists of amino acid residues −
26 to 147 of SEQ ID NO;
2;(c) a protein whose amino acid sequence consists of amino acid residues 1 to 147 of SEQ ID NO;
2;(d) a protein whose amino acid sequence consists of amino acid residues 25 to 147 of SEQ ID NO;
2;(e) a protein whose amino acid sequence consists of a portion of SEQ ID NO;
2, wherein said portion is at least 30 contiguous amino acid residues in length;(f) a protein whose amino acid sequence consists of a portion of SEQ ID NO;
2, wherein said portion is at least 50 contiguous amino acid residues in length;(g) a protein whose sequence consists of the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC™
Deposit Number 75927;(h) a protein whose sequence consists of the amino acid sequence of the full-length polypeptide, excluding the N-terminal methionine residue, encoded by the cDNA contained in ATCC™
Deposit Number 75927; and(i) a protein whose sequence consists of the amino acid sequence of the extracellular domain of the polypeptide encoded by the cDNA contained in ATCC™
Deposit Number 75927. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An isolated antibody or fragment thereof that specifically binds a tumor necrosis factor-gamma protein purified from a cell culture wherein said tumor necrosis factor-gamma protein is encoded by a polynucleotide encoding amino acids −
- 27 to 147 of SEQ ID NO;
2. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
- 27 to 147 of SEQ ID NO;
Specification