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Methods for making and using SPR microarrays

  • US 8,094,315 B2
  • Filed: 12/08/2008
  • Issued: 01/10/2012
  • Est. Priority Date: 12/06/2005
  • Status: Active Grant
First Claim
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1. A method of determining binding between a binding group and a biomolecule comprising:

  • a) providing an article including;

    i) a substrate;

    ii) a first metal film overlying the substrate;

    iii) a second thin metal selected from the group consisting of Ti, Zr, Al, Cr, Hf, V, Ta, W and Pb, wherein the thin metal film includes a proximal surface and a distal surface, wherein the proximal surface is proximal to the first metal film and the distal surface is distal to the first metal film; and

    iv) the binding group attached to the distal surface of the second thin metal film;

    b) contacting the article with the biomolecule; and

    c) measuring a surface plasmon resonance signal to determine the binding between the binding group and the biomolecule.

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