Peritoneal dialysis methods and apparatus
First Claim
1. A peritoneal dialysis system, comprising:
- a first fluid line that carries a fluid stream from a peritoneal cavity of a user;
a separator that separates the fluid stream into a relatively protein-rich stream and a relatively protein-free stream, wherein the relatively protein-rich stream averages at least 15% (by vol) of the fluid stream over at least some period of time; and
a processing line that includes a sorbent system that is configured to remove at least one toxin from at least some of the protein-rich stream to thereby allow production of a modified dialysate stream;
a second fluid line that introduces at least some of the modified dialysate stream into the peritoneal cavity; and
wherein at least some of the sorbent system includes an enzyme that is immobilized on a substrate with greater than Van der Waals forces.
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Accused Products
Abstract
A peritoneal-based (“bloodless”) artificial kidney processes peritoneal fluid without need for additional fluids (“waterless”). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) (“dialysate-pheresis”). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to “reverse flush” the separator to maintain its patency and the excess discarded for fluid-balance regulation. Compared to prior art, immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys.
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Citations
22 Claims
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1. A peritoneal dialysis system, comprising:
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a first fluid line that carries a fluid stream from a peritoneal cavity of a user; a separator that separates the fluid stream into a relatively protein-rich stream and a relatively protein-free stream, wherein the relatively protein-rich stream averages at least 15% (by vol) of the fluid stream over at least some period of time; and a processing line that includes a sorbent system that is configured to remove at least one toxin from at least some of the protein-rich stream to thereby allow production of a modified dialysate stream; a second fluid line that introduces at least some of the modified dialysate stream into the peritoneal cavity; and wherein at least some of the sorbent system includes an enzyme that is immobilized on a substrate with greater than Van der Waals forces. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification