Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
First Claim
1. A method of therapeutically treating cancer in a patient diagnosed with cancer,wherein the cancer is basal cell carcinoma, medulloblastoma, squamous cell carcinoma, carcinosarcoma, adenocystic carcinoma, epidermoid carcinoma, nasopharyngeal carcinoma, renal cell carcinoma, a papilloma, an epidermoidoma, a glioma, meningioma, a neuroectodermal tumor, an ependymoma, pineoblastoma, hemangioma, pancreatic cancer, adenocarcinoma, rhabdomyosarcoma, glioblastoma, sarcoma, thyroid carcinoma, bone cancer, lung cancer, chondrosarcoma, breast cancer, urogenital cancer, kidney cancer, bladder cancer, ureter cancer, prostate cancer, adrenal cancer, gastrointestinal cancer, stomach cancer, intestinal cancer, keratoacanthoma, or malignant hepatoma,comprising administering to the patient a steroidal alkaloid represented in general Formula II or a homo-derivative thereof:
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Abstract
The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
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Citations
19 Claims
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1. A method of therapeutically treating cancer in a patient diagnosed with cancer,
wherein the cancer is basal cell carcinoma, medulloblastoma, squamous cell carcinoma, carcinosarcoma, adenocystic carcinoma, epidermoid carcinoma, nasopharyngeal carcinoma, renal cell carcinoma, a papilloma, an epidermoidoma, a glioma, meningioma, a neuroectodermal tumor, an ependymoma, pineoblastoma, hemangioma, pancreatic cancer, adenocarcinoma, rhabdomyosarcoma, glioblastoma, sarcoma, thyroid carcinoma, bone cancer, lung cancer, chondrosarcoma, breast cancer, urogenital cancer, kidney cancer, bladder cancer, ureter cancer, prostate cancer, adrenal cancer, gastrointestinal cancer, stomach cancer, intestinal cancer, keratoacanthoma, or malignant hepatoma, comprising administering to the patient a steroidal alkaloid represented in general Formula II or a homo-derivative thereof:
Specification