Systems and methods for determining vessel compliance
First Claim
1. A method for determining vessel compliance, the method comprising the steps of:
- introducing a device into a site within a vessel, the device comprising;
a pair of excitation electrodes positioned along a portion of the device; and
a pair of detection electrodes positioned along a portion of the device, the pair of detection electrodes comprising two detection electrodes having a known distance from one another, the pair of detection electrodes physically positioned in between the pair of excitation electrodes;
operating the device in connection with two or more fluid injections in the vessel at or near the site to obtain two or more conductance values, each of the two or more fluid injections having a known conductivity;
calculating a first vessel parameter of the site based on at least two of the two or more conductance values and the conductivities of at least two of the two or more fluid injections;
calculating a second vessel parameter of the site based on at least two of the two or more conductance values and the conductivities of at least two of the two or more fluid injections;
calculating a change in vessel parameter based upon the first vessel parameter and the second vessel parameter;
calculating vessel compliance based upon the relationship between the change in vessel parameter and a change in pressure during a cardiac cycle; and
calculating an index of compliance based in part upon a difference between the first vessel parameter and the second vessel parameter divided by the first vessel parameter.
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Accused Products
Abstract
The disclosure of the present application provides for systems and methods for determining a phasic change in a vessel and vessel compliance. In at least one exemplary method for determining a phasic change in a vessel, the method comprises the steps of introducing a device into a site within a vessel, operating the device in connection with two or more fluid injections in the vessel to obtain two or more conductance values, calculating a parallel conductance value and a total conductance value, and calculating a phasic change in at least one vessel parameter based in part upon the calculated parallel conductance value and the calculated total conductance value. In an exemplary method for determining vessel compliance, the method comprises, in part, the steps of calculating a first vessel parameter and a second vessel parameter based on at least two conductance values, calculating a change in vessel parameter based upon the first and second vessel parameters, and calculating vessel compliance based upon the relationship between the change in vessel parameter and a change in pressure during a cardiac cycle.
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Citations
19 Claims
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1. A method for determining vessel compliance, the method comprising the steps of:
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introducing a device into a site within a vessel, the device comprising; a pair of excitation electrodes positioned along a portion of the device; and a pair of detection electrodes positioned along a portion of the device, the pair of detection electrodes comprising two detection electrodes having a known distance from one another, the pair of detection electrodes physically positioned in between the pair of excitation electrodes; operating the device in connection with two or more fluid injections in the vessel at or near the site to obtain two or more conductance values, each of the two or more fluid injections having a known conductivity; calculating a first vessel parameter of the site based on at least two of the two or more conductance values and the conductivities of at least two of the two or more fluid injections; calculating a second vessel parameter of the site based on at least two of the two or more conductance values and the conductivities of at least two of the two or more fluid injections; calculating a change in vessel parameter based upon the first vessel parameter and the second vessel parameter; calculating vessel compliance based upon the relationship between the change in vessel parameter and a change in pressure during a cardiac cycle; and calculating an index of compliance based in part upon a difference between the first vessel parameter and the second vessel parameter divided by the first vessel parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for determining vessel compliance, the method comprising the steps of:
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introducing a device into a site within a vessel, the device comprising a pair of excitation electrodes and a pair of detection electrodes positioned therebetween; operating the device to obtain two or more conductance values; calculating a change in cross-sectional area based in part upon the two or more conductance values; calculating vessel compliance based upon the relationship between the change in cross-sectional area and a change in pressure during a cardiac cycle; and calculating an index of compliance based in part upon a difference between the first vessel parameter and the second vessel parameter divided by the first vessel parameter.
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19. A system for determining vessel compliance, the system comprising:
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a device capable of acquiring conductance data, the device comprising; a pair of excitation electrodes positioned along a portion of the device; and a pair of detection electrodes positioned along a portion of the device, the pair of detection electrodes comprising two detection electrodes having a known distance from one another, the pair of detection electrodes physically positioned in between the pair of excitation electrodes along a portion of the device; an injection source for injecting one or more solutions through the device to a target site; a current source for providing current to the device; and a data acquisition and processing system that receives conductance data from the device, wherein the data acquisition and processing system is operable to calculate vessel compliance based upon; a. a calculated change in vessel parameter based upon a calculated first vessel parameter and a calculated second vessel parameter, the calculated first vessel parameter and a calculated second vessel parameter calculated based upon the conductance data acquired from the device; and b. a calculated relationship between the calculated change in vessel parameter and a change in pressure during a cardiac cycle; wherein the data acquisition and processing system is further operable to calculate an index of compliance based in part upon a difference between the first vessel parameter and the second vessel parameter divided by the first vessel parameter.
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Specification