Variable region sequences of IL-31 monoclonal antibodies
First Claim
1. A monoclonal antibody or antibody fragment that competes for specifically binding to a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 2 wherein the monoclonal antibody is selected from the group consisting of;
a) a monoclonal antibody comprisingi) a heavy chain variable domain comprising a first CDR sequence consisting of amino acid sequence SEQ ID NO;
51, a second CDR sequence consisting of SEQ ID NO;
52 or SEQ ID NO;
57, and a third CDR sequence consisting of SEQ ID NO;
53; and
ii) a light chain variable domain comprising a CDR sequence consisting of amino acid sequence SEQ ID NO;
54, a second CDR sequence consisting of SEQ ID NO;
55, and a third CDR sequence consisting of SEQ ID NO;
56; and
b) a monoclonal antibody comprisingi) a heavy chain variable domain comprising a first CDR sequence consisting of amino acid sequence SEQ ID NO;
63, a second CDR sequence consisting of SEQ ID NO;
64, and a third CDR sequence consisting of SEQ ID NO;
65; and
ii) a light chain variable domain comprising a CDR sequence consisting of amino acid sequence SEQ ID NO;
66, a second CDR sequence consisting of SEQ ID NO;
67, and a third CDR sequence consisting of SEQ ID NO;
68.
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Abstract
The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention provides the hybridomas that generate the monoclonal antibodies and the amino acid sequences of the variable regions of the monoclonal antibodies and chimeric antibodies comprising the amino acid sequences of the light and heavy chain variable regions.
71 Citations
22 Claims
-
1. A monoclonal antibody or antibody fragment that competes for specifically binding to a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 2 wherein the monoclonal antibody is selected from the group consisting of;
a) a monoclonal antibody comprising i) a heavy chain variable domain comprising a first CDR sequence consisting of amino acid sequence SEQ ID NO;
51, a second CDR sequence consisting of SEQ ID NO;
52 or SEQ ID NO;
57, and a third CDR sequence consisting of SEQ ID NO;
53; andii) a light chain variable domain comprising a CDR sequence consisting of amino acid sequence SEQ ID NO;
54, a second CDR sequence consisting of SEQ ID NO;
55, and a third CDR sequence consisting of SEQ ID NO;
56; andb) a monoclonal antibody comprising i) a heavy chain variable domain comprising a first CDR sequence consisting of amino acid sequence SEQ ID NO;
63, a second CDR sequence consisting of SEQ ID NO;
64, and a third CDR sequence consisting of SEQ ID NO;
65; andii) a light chain variable domain comprising a CDR sequence consisting of amino acid sequence SEQ ID NO;
66, a second CDR sequence consisting of SEQ ID NO;
67, and a third CDR sequence consisting of SEQ ID NO;
68. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- 2 wherein the monoclonal antibody is selected from the group consisting of;
-
11. A monoclonal antibody or antibody fragment comprising
i) a heavy chain variable domain comprising a first CDR sequence consisting of amino acid sequence SEQ ID NO: - 51, a second CDR sequence consisting of SEQ ID NO;
52 or SEQ ID NO;
57, and a third CDR sequence consisting of SEQ ID NO;
53; andii) a light chain variable domain comprising a CDR sequence consisting of amino acid sequence SEQ ID NO;
54, a second CDR sequence consisting of SEQ ID NO;
55, and a third CDR sequence consisting of SEQ ID NO;
56.
- 51, a second CDR sequence consisting of SEQ ID NO;
-
12. A monoclonal antibody or antibody fragment comprising
i) a heavy chain variable domain comprising a first CDR sequence consisting of amino acid sequence SEQ ID NO: - 63, a second CDR sequence consisting of SEQ ID NO;
64, and a third CDR sequence consisting of SEQ ID NO;
65; andii) a light chain variable domain comprising a CDR sequence consisting of amino acid sequence SEQ ID NO;
66, a second CDR sequence consisting of SEQ ID NO;
67, and a third CDR sequence consisting of SEQ ID NO;
68.
- 63, a second CDR sequence consisting of SEQ ID NO;
-
13. A monoclonal antibody or antibody fragment that competes for specifically binding to a polypeptide consistong of the amino acid sequence of SEQ ID NO:
- 2 wherein the monoclonal antibody comprising a light chain variable region and a heavy chain variable region selected from the group consisting of;
a) a light chain variable region comprising the amino acid sequence of SEQ ID NO;
8 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
9; andb) a light chain variable region comprising the amino acid sequence of SEQ ID NO;
10 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
11. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
- 2 wherein the monoclonal antibody comprising a light chain variable region and a heavy chain variable region selected from the group consisting of;
-
21. A monoclonal antibody or antibody fragment comprising
a) a light chain variable region comprising the amino acid sequence of SEQ ID NO: - 8 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
9.
- 8 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
-
22. A monoclonal antibody or antibody fragment comprising
a) a light chain variable region comprising the amino acid sequence of SEQ ID NO: - 10 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
11.
- 10 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
Specification