Forming coils

• US 8,101,197 B2
• Filed: 12/19/2005
• Issued: 01/24/2012
• Est. Priority Date: 12/19/2005
• Status: Expired due to Fees

• Current Assignee: Stryker European Operations Holdings, LLC (Stryker Corporation)
• Original Assignee: Stryker Corporation, Stryker Nv Operations Limited (Stryker Corporation)
• Inventors: Buiser, Marcia S., Lee, Elaine
• Primary Examiner(s): Foley, Shanon A
• Application Number:
  US11/311,617
• Publication Number:
  US 20070141099A1
• Time in Patent Office: 2,227 Days
• Field of Search: None
• US Class Current: 424/422
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00898 expandable upon contact with fluid
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B05D 1/18 performed by dipping
• CPC Class Codes: B05D 7/20 to wires for insulating electric cables H01B13/16

Abstract

Coils, such as embolic coils, can include a substrate; and a porous material supported by the substrate. Related methods, devices, and compositions, can include: injecting a material into a container containing the coil; and forming the material into a coating that is supported by the coil and/or contacting the coil with a composition comprising a first polymer and a gelling precursor; and forming the composition into a coating that is supported by the coil.

Claims

1. A method of coating a coil, the method comprising:

injecting a material comprising a first polymer and a gelling precursor into a container containing the coil;

gelling the gelling precursor to provide a first coating on the coil, the coating comprising the first polymer and the gelled precursor;

cross-linking the first polymer in the first coating to provide a second coating on the coil, the second coating comprising the cross-linked first polymer and the gelled precursor; and

removing the gelled precursor from the second coating to provide a third coating on the coil, the third coating comprising the cross-linked first polymer having pores therein.

2. The method of claim 1, wherein the coil is an embolic coil.

3. The method of claim 1, wherein the first polymer comprises a polysaccharide.

4. The method of claim 1, wherein the first polymer comprises alginate.

5. The method of claim 1, wherein the first polymer comprises polyvinyl alcohol.

6. The method of claim 1, wherein the material further comprises a second polymer different from the first polymer.

7. The method of claim 1, wherein gelling the gelling precursor comprises contacting the material with a gelling agent.

8. The method of claim 7, wherein contacting the material with the gelling agent comprises delivering the gelling agent into the container.

9. The method of claim 1, wherein cross-linking the first polymer comprises contacting the material with a cross-linking agent.

10. The method of claim 1, further comprising contacting the third coating with a therapeutic agent.

11. The method of claim 1, wherein the material comprises a therapeutic agent.

12. The method of claim 1, wherein the container comprises a tubular member.

13. The method of claim 1, further comprising removing the coil from the container.

14. The method of claim 13, wherein the container comprises a bioerodible or bioabsorbable material, and removing the coil from the container comprises eroding or absorbing the container.