Medical device for analyte monitoring and drug delivery
First Claim
1. An ingestible medical device having an exterior surface and an interior surface, said ingestible medical device comprising:
- (a) a microarray comprising a polypeptide bioactive agent capable of interacting with a disease marker biological analyte, and further comprising a plurality of reaction sites on a continuous surface, each site of said plurality comprising affixed thereto the polypeptide bioactive agent;
(b) a reservoir comprising a therapeutic agent;
(c) a microchip comprising;
i) an optical microarray scanning device that is configured to optically detect signals from the plurality of reaction sites on the continuous surface, wherein the signals are indicative of a physical parameter representing an interaction between the disease marker biological analyte with said polypeptide bioactive agent at said plurality of reaction sites;
ii) a biometric recognition device that is configured to compare said physical parameter data with an analyte interaction profile;
iii) a therapeutic agent releasing device that is configured to control release of said therapeutic agent from said reservoir; and
iv) an interface device that is configured to facilitate communications between said microarray scanning device and said biometric recognition device; and
(d) a biocompatible polymer coating, coated on the exterior surface of said ingestible medical device.
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Accused Products
Abstract
The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.
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Citations
29 Claims
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1. An ingestible medical device having an exterior surface and an interior surface, said ingestible medical device comprising:
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(a) a microarray comprising a polypeptide bioactive agent capable of interacting with a disease marker biological analyte, and further comprising a plurality of reaction sites on a continuous surface, each site of said plurality comprising affixed thereto the polypeptide bioactive agent; (b) a reservoir comprising a therapeutic agent; (c) a microchip comprising; i) an optical microarray scanning device that is configured to optically detect signals from the plurality of reaction sites on the continuous surface, wherein the signals are indicative of a physical parameter representing an interaction between the disease marker biological analyte with said polypeptide bioactive agent at said plurality of reaction sites; ii) a biometric recognition device that is configured to compare said physical parameter data with an analyte interaction profile; iii) a therapeutic agent releasing device that is configured to control release of said therapeutic agent from said reservoir; and iv) an interface device that is configured to facilitate communications between said microarray scanning device and said biometric recognition device; and (d) a biocompatible polymer coating, coated on the exterior surface of said ingestible medical device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification