Fluorescent sensor based on two fluorescent moieties one of which is a semiconductor nanocrystal and methods of using and making
First Claim
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1. A composition comprising:
- a first fluorescent moiety;
a second fluorescent moiety chemically bound to the first fluorescent moiety;
wherein the first fluorescent moiety is capable of transferring energy to the second fluorescent moiety when excited, or the second fluorescent moiety is capable of transferring energy to the first fluorescent moiety when excited,the first fluorescent moiety is a semiconductor nanocrystal including a core including a first semiconductor material, one or more optional overcoatings including a second semiconductor material on a surface of the core, and an outer layer coated on the core or, if present, coated on the one or more optional overcoatings, andwherein the second fluorescent moiety is capable of binding an analyte.
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Abstract
Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice versa.
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Citations
30 Claims
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1. A composition comprising:
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a first fluorescent moiety; a second fluorescent moiety chemically bound to the first fluorescent moiety; wherein the first fluorescent moiety is capable of transferring energy to the second fluorescent moiety when excited, or the second fluorescent moiety is capable of transferring energy to the first fluorescent moiety when excited, the first fluorescent moiety is a semiconductor nanocrystal including a core including a first semiconductor material, one or more optional overcoatings including a second semiconductor material on a surface of the core, and an outer layer coated on the core or, if present, coated on the one or more optional overcoatings, and wherein the second fluorescent moiety is capable of binding an analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of detecting an analyte, comprising:
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illuminating a composition with an excitation wavelength, wherein the composition includes; a first fluorescent moiety; a second fluorescent moiety chemically bound to the first fluorescent moiety; wherein the first fluorescent moiety is capable of transferring energy to the second fluorescent moiety when excited, or the second fluorescent moiety is capable of transferring energy to the first fluorescent moiety when excited, the first fluorescent moiety is a semiconductor nanocrystal including a core including a first semiconductor material, one or more optional overcoatings including a second semiconductor material on a surface of the core, and an outer layer coated on the core or, if present, coated on the one or more optional overcoatings, and wherein the second fluorescent moiety is capable of binding an analyte; and measuring a fluorescent emission of the composition. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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20. A method of making a composition comprising:
linking a first fluorescent moiety to a second fluorescent moiety, wherein the first fluorescent moiety is a semiconductor nanocrystal including a core including a first semiconductor material, one or more optional overcoatings including a second semiconductor material on a surface of the core, and an outer layer coated on the core or, if present, coated on the one or more optional overcoatings, and wherein the second fluorescent moiety is capable of binding an analyte. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
Specification