Compositions and methods for the modulation of JNK proteins
First Claim
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1. A method of reducing lipid levels in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an antisense compound targeted to a JNK1 nucleic acid, thereby reducing lipid levels.
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Abstract
The invention provides compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase 1 (JNK1 protein.
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30 Claims
- 1. A method of reducing lipid levels in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an antisense compound targeted to a JNK1 nucleic acid, thereby reducing lipid levels.
- 6. A method of treating obesity or metabolic syndrome in a subject comprising administering to said subject a lipid-lowering agent and a therapeutically effective amount of an antisense compound targeted to a JNK 1 nucleic acid, wherein said antisense compound targeted to said JNK 1 nucleic acid reduces lipid levels in said subject, thereby treating obesity or metabolic syndrome.
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