Immunoglobulin insertions, deletions and substitutions
First Claim
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1. A protein comprising an IgG2 Fc variant of a Fc IgG2 parent polypeptide, said parent polypeptide having the sequence of amino acids 106 to 326 of SEQ ID NO:
- 2, wherein the amino acid modifications of said IgG2 variant consist of;
a) substitution at positions 113-115 of SEQ ID NO;
2 with Glu-Leu-Leu;
b) an insertion of a Gly amino acid residue after position 115 of SEQ ID NO;
2;
c) a substitution at position 118 of SEQ ID NO;
2 with an Asp amino acid residue;
d) a substitution at position 206 of SEQ ID NO;
2 with an Ala amino acid residue; and
e) a substitution at position 211 of SEQ ID NO;
2 with a Glu amino acid residue.
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Abstract
An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
275 Citations
8 Claims
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1. A protein comprising an IgG2 Fc variant of a Fc IgG2 parent polypeptide, said parent polypeptide having the sequence of amino acids 106 to 326 of SEQ ID NO:
- 2, wherein the amino acid modifications of said IgG2 variant consist of;
a) substitution at positions 113-115 of SEQ ID NO;
2 with Glu-Leu-Leu;b) an insertion of a Gly amino acid residue after position 115 of SEQ ID NO;
2;c) a substitution at position 118 of SEQ ID NO;
2 with an Asp amino acid residue;d) a substitution at position 206 of SEQ ID NO;
2 with an Ala amino acid residue; ande) a substitution at position 211 of SEQ ID NO;
2 with a Glu amino acid residue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 2, wherein the amino acid modifications of said IgG2 variant consist of;
Specification