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Immunoglobulin insertions, deletions and substitutions

  • US 8,101,720 B2
  • Filed: 01/25/2008
  • Issued: 01/24/2012
  • Est. Priority Date: 10/21/2004
  • Status: Active Grant
First Claim
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1. A protein comprising an IgG2 Fc variant of a Fc IgG2 parent polypeptide, said parent polypeptide having the sequence of amino acids 106 to 326 of SEQ ID NO:

  • 2, wherein the amino acid modifications of said IgG2 variant consist of;

    a) substitution at positions 113-115 of SEQ ID NO;

    2 with Glu-Leu-Leu;

    b) an insertion of a Gly amino acid residue after position 115 of SEQ ID NO;

    2;

    c) a substitution at position 118 of SEQ ID NO;

    2 with an Asp amino acid residue;

    d) a substitution at position 206 of SEQ ID NO;

    2 with an Ala amino acid residue; and

    e) a substitution at position 211 of SEQ ID NO;

    2 with a Glu amino acid residue.

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