Method and medicament for inhibiting the expression of a given gene
First Claim
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1. A medicament comprising:
- an isolated double stranded RNA (dsRNA) consisting of two separate complementary oligoribonucleotide strands that are linked by a linker, wherein said linker comprises a covalent linker,wherein each of said strands consists of 21 nucleotides in length,wherein the dsRNA does not comprise a full length RNA transcript of a mammalian target gene,wherein one strand of said dsRNA is complementary to less than the full length of an RNA transcript of said mammalian target gene,and wherein said dsRNA is capable of specifically inhibiting the expression of said mammalian target gene.
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Abstract
The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated RNA.
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Citations
24 Claims
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1. A medicament comprising:
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an isolated double stranded RNA (dsRNA) consisting of two separate complementary oligoribonucleotide strands that are linked by a linker, wherein said linker comprises a covalent linker, wherein each of said strands consists of 21 nucleotides in length, wherein the dsRNA does not comprise a full length RNA transcript of a mammalian target gene, wherein one strand of said dsRNA is complementary to less than the full length of an RNA transcript of said mammalian target gene, and wherein said dsRNA is capable of specifically inhibiting the expression of said mammalian target gene. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A medicament comprising:
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an isolated double stranded RNA (dsRNA) consisting of two separate complementary oligoribonucleotide strands that are linked by a linker, wherein said linker comprises a labile linker, wherein each of said strands consists of 21 nucleotides in length, wherein the dsRNA does not comprise a full length RNA transcript of a mammalian target gene, wherein one strand of said dsRNA is complementary to less than the full length of an RNA transcript of said mammalian target gene, and wherein said dsRNA is capable of specifically inhibiting the expression of said mammalian target gene. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification