Method of differentiating between blood and control solutions containing a common analyte

• US 8,102,517 B2
• Filed: 12/12/2005
• Issued: 01/24/2012
• Est. Priority Date: 12/13/2004
• Status: Active Grant

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Marfurt, Karen L.
• Primary Examiner(s): LAUCHMAN, LAYLA G
• Application Number:
  US11/792,194
• Publication Number:
  US 20080145878A1
• Time in Patent Office: 2,234 Days
• Field of Search: 356/39, 436/44, 422/50
• US Class Current: 356/39
• CPC Class Codes: G01N 1/28 Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Qmounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 ; laboratory gas handling apparatus B01L5/00
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/96 involving blood or serum control standard
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/110833 Utilizing a moving indicator strip or tape
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples.

Claims

1. An optical instrument for correlating the glucose content of blood samples with the optical response obtained by contact of the sample with a test strip adapted to provide the optical response by reaction with the blood sample, the optical instrument comprising a light-emitting diode to excite a response from a labeling substance in a control solution used to distinguish the control solution from the blood samples, wherein the labeling substance has a peak absorbance of light distinguished from the peak absorbance of an indicator used to measure the amount of glucose present.

2. The optical instrument of claim 1, wherein the optical instrument compiles glucose measurements and excludes such measurements made of control solutions.

3. The optical instrument of claim 1, wherein the substance is indocyanine green.

4. The optical instrument of claim 3, wherein the labeling substance is distinguished from a tetrazolium salt indicator.