Assessment of medical conditions
First Claim
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1. A method for assessing a medical condition, the method comprising:
- obtaining a first baseline template corresponding to an average of results of a first calculation performed on multiple segments of a first electrical signal acquired at a first time;
obtaining a first captured template corresponding to an average of results of the first calculation performed on multiple segments of a second electrical signal acquired a second time later than the first time;
obtaining a second baseline template corresponding to an average of results of a second calculation performed on multiple segments of the first electrical signal;
obtaining a second captured template corresponding to an average of results of the second calculation performed on multiple segments of the second electrical signal;
calculating a first variance between the first baseline and captured templates;
calculating a second variance between the second baseline and captured templates, the first and second variances providing unequal indications of the medical condition;
scaling the first and second variances by first and second weighting factors, respectively, to produce first and second scaled variances indicative of the relative importance of the variances; and
calculating a first sum of the first and second scaled variances.
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Abstract
The present invention is directed to methods for analyzing electrical signals generated by biological tissues, such as muscles (e.g., cardiac or skeletal muscle) and tissue within the nervous system (e.g., neurons within the central and peripheral nervous systems). The tissue may be a patient'"'"'s own, or it may have been transplanted into the patient from a donor organism or from a tissue or cell culture. The result of the analysis indicates the condition of the tissue, and results obtained over time can alert a patient or health care professional to changes in that condition.
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Citations
27 Claims
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1. A method for assessing a medical condition, the method comprising:
- obtaining a first baseline template corresponding to an average of results of a first calculation performed on multiple segments of a first electrical signal acquired at a first time;
obtaining a first captured template corresponding to an average of results of the first calculation performed on multiple segments of a second electrical signal acquired a second time later than the first time;
obtaining a second baseline template corresponding to an average of results of a second calculation performed on multiple segments of the first electrical signal;
obtaining a second captured template corresponding to an average of results of the second calculation performed on multiple segments of the second electrical signal;
calculating a first variance between the first baseline and captured templates;
calculating a second variance between the second baseline and captured templates, the first and second variances providing unequal indications of the medical condition;
scaling the first and second variances by first and second weighting factors, respectively, to produce first and second scaled variances indicative of the relative importance of the variances; and
calculating a first sum of the first and second scaled variances. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- obtaining a first baseline template corresponding to an average of results of a first calculation performed on multiple segments of a first electrical signal acquired at a first time;
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10. A system for assessing a medical condition, the system comprising:
- a registering unit for capturing a first electrical signal at a first time and a second electrical signal at a second time later than the first time; and
a controller configured to;
obtain a first baseline template corresponding to an average of results of a first calculation performed on multiple segments of a first electrical signal acquired at a first time;
obtain a first captured template corresponding to an average of results of the first calculation performed on multiple segments of a second electrical signal acquired at a second time later than the first time;
obtain a second baseline template corresponding to an average of results of a second calculation performed on multiple segments of the first electrical signal;
obtain a second captured template corresponding to an average of results of the second calculation performed on multiple segments of the second electrical signal;
calculate a first variance between the first baseline and captured templates;
calculate a second variance between the second baseline and captured templates, the first and second variances providing unequal indications of the medical condition;
scale the first and second variances by first and second weighting factors, respectively, to produce first and second scaled variances indicative of the relative importance of the variances; and
calculate a first sum of the first and second scaled variances. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
- a registering unit for capturing a first electrical signal at a first time and a second electrical signal at a second time later than the first time; and
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19. A computer program product for assessing a medical condition, the computer program product being tangibly stored on machine readable media, comprising instructions operable to cause one or more processors to:
- obtain a first baseline template corresponding to an average of results of a first calculation performed on multiple segments of a first electrical signal acquired at a first time;
obtain a first captured template corresponding to an average of results of the first calculation performed on multiple segments of a second electrical signal acquired a second time later than the first time;
obtain a second baseline template corresponding to an average of results of a second calculation performed on multiple segments of the first electrical signal;
obtain a second captured template corresponding to an average of results of the second calculation performed on multiple segments of the second electrical signal;
calculate a first variance between the first baseline and captured templates;
calculate a second variance between the second baseline and captured templates, the first and second variances providing unequal indications of the medical condition;
scaling the first and second variances by first and second weighting factors, respectively, to produce first and second scaled variances indicative of the relative importance of the variances; and
calculate a first sum of the first and second scaled variances. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
- obtain a first baseline template corresponding to an average of results of a first calculation performed on multiple segments of a first electrical signal acquired at a first time;
Specification