Method of stimulation fastigium nucleus to treat neurological disorders

• US 8,103,350 B2
• Filed: 06/11/2007
• Issued: 01/24/2012
• Est. Priority Date: 07/16/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation), Advanced Bionics Corporation (Sonova Holding AG)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Wallace, Michael P., Makous, James Carl
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Bays, Pamela M
• Application Number:
  US11/761,330
• Publication Number:
  US 20070233202A1
• Time in Patent Office: 1,688 Days
• Field of Search: 128/898, 128/899, 600/378, 607/2, 607/45, 607/117, 607/118, 607/62, 607/116, 607/3
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke

Abstract

A method of treating a neurological disorder comprises introducing an electrical stimulation lead within a patient'"'"'s head, locating the stimulation lead within the 4^th ventricle of the patient'"'"'s head, and placing the stimulation lead adjacent the fastigium nucleus of the patient'"'"'s brain. The method may further comprise stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder, for example, by increasing the flow of blood within the patient'"'"'s brain.

Claims

1. A method of treating a neurological disorder in a patient, comprising:

introducing an electrical stimulation lead within the patient'"'"'s head;

locating the stimulation lead within the ventricular system of the patient;

introducing the stimulation lead from the ventricular system into the 4th ventricle of the patient'"'"'s head; and

placing the stimulation lead adjacent the fastigium nucleus of the patient'"'"'s brain.

2. The method of claim 1, wherein the neurological disorder is a disorder that can be alleviated by increasing blood flow within the patient'"'"'s brain.

3. The method of claim 1, wherein the neurological disorder is an acute stroke.

4. The method of claim 1, wherein the neurological disorder is selected from a group consisting of acute stroke, chronic transient ischemic attack, cerebral vasospasm, and Alzheimer'"'"'s Disease.

5. The method of claim 1, wherein the stimulation lead is placed into direct contact with the fastigium nucleus.

6. The method of claim 1, wherein the stimulation lead is introduced into the patient'"'"'s head by advancing the stimulation lead within the intrathecal space along the spinal column of the patient.

7. The method of claim 6, wherein the stimulation lead is located within the 4^th ventricle by advancing the stimulation lead from the intrathecal space into the 4^th ventricle via the foramen of Magendie.

8. The method of claim 6, wherein the stimulation lead is located within the 4^th ventricle by advancing the stimulation lead from the intrathecal space into the 4^th ventricle via one of the foramina of Luschka.

9. The method of claim 1, wherein the stimulation lead is introduced into the patient'"'"'s head via a burr hole.

10. The method of claim 1, wherein the stimulation lead is located within the 4^th ventricle by introducing the stimulation lead into the 3^rd ventricle of the patient'"'"'s head and advancing the stimulation lead from the 3^rd ventricle into the 4^th ventricle via the Sylvian aqueduct.

11. The method of claim 10, wherein the stimulation lead is introduced into the 3^rd ventricle by advancing the stimulation lead from a burr hole through the frontal lobe of the patient'"'"'s brain into the lateral ventricle of the patient'"'"'s head, and from the lateral ventricle into the 3^rd ventricle via the foramen of Monroe.

12. The method of claim 1, further comprising stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder.

13. The method of claim 12, wherein the stimulation of the fastigium nucleus increases the flow of blood within the patient'"'"'s brain.

14. The method of claim 13, further comprising:

introducing another electrical stimulation lead within the head of the patient;

placing the other stimulation lead adjacent cortical tissue of the patient'"'"'s brain; and

stimulating the cortical tissue with the other stimulation lead to rehabilitate the patient.

15. A method of treating a neurological disorder in a patient, comprising:

introducing an electrical stimulation lead within the patient'"'"'s head by advancing the stimulation lead within the intrathecal space along the spinal column of the patient;

delivering the stimulation lead from the intrathecal space into at least one ventricle of the patient'"'"'s head; and

placing the stimulation lead adjacent the fastigium nucleus of the patient'"'"'s brain.

16. The method of claim 15, wherein the stimulation lead is delivered into the 4^th ventricle by advancing the stimulation lead from the intrathecal space into the 4^th ventricle via at least one of the foramen of Magendie and one of the foramina of Luschka.

17. The method of claim 15, wherein the stimulation lead is delivered into the 4^th ventricle by advancing the stimulation lead from the intrathecal space into the 4^th ventricle via the foramen of Magendie.

18. The method of claim 15, wherein the stimulation lead is delivered into the 4^th ventricle by advancing the stimulation lead from the intrathecal space into the 4^th ventricle via one of the foramina of Luschka.