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Treatment of neoplasms with viruses

  • US 8,105,578 B2
  • Filed: 01/29/2007
  • Issued: 01/31/2012
  • Est. Priority Date: 10/09/1997
  • Status: Expired due to Fees
First Claim
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1. A method of infecting a cell of a neoplasm in a mammal with a virus, the method comprising administering an interferon-sensitive, replication-competent vaccinia virus to the mammal,wherein the virus comprises one or more mutations in one or more genes selected from the group consisting of K3L, E3L, and B18R,wherein the one or more mutations increases the interferon sensitivity of the virus.

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