Treatment of neoplasms with viruses
First Claim
1. A method of infecting a cell of a neoplasm in a mammal with a virus, the method comprising administering an interferon-sensitive, replication-competent vaccinia virus to the mammal,wherein the virus comprises one or more mutations in one or more genes selected from the group consisting of K3L, E3L, and B18R,wherein the one or more mutations increases the interferon sensitivity of the virus.
3 Assignments
0 Petitions
Accused Products
Abstract
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
-
Citations
63 Claims
-
1. A method of infecting a cell of a neoplasm in a mammal with a virus, the method comprising administering an interferon-sensitive, replication-competent vaccinia virus to the mammal,
wherein the virus comprises one or more mutations in one or more genes selected from the group consisting of K3L, E3L, and B18R, wherein the one or more mutations increases the interferon sensitivity of the virus.
Specification