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Methods of antagonizing signal transduction in dorsal root ganglion cells

  • US 8,105,591 B2
  • Filed: 03/30/2011
  • Issued: 01/31/2012
  • Est. Priority Date: 01/10/2006
  • Status: Active Grant
First Claim
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1. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject in need thereof, comprising administering a monoclonal antibody or a binding fragment thereof to the subject, wherein the monoclonal antibody or binding fragment thereof specifically binds to a first receptor consisting of amino acid residues 1-662 of SEQ ID NO:

  • 8, or a second receptor consisting of amino acid residues 1-979 of SEQ ID NO;

    16, or a heterodimeric receptor comprising the first and second receptors, and wherein after administration the signal transduction is reduced.

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