Process for in vivo treatment of specific biological targets in bodily fluids
First Claim
1. A process for treating biological targets in a fluid of a biological organism, comprisingintroducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber with an inner diameter of 15 microns to 150 microns for conveying a flow of the fluid, the flow chamber having a capture zone comprising a target-specific binding agent,wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
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Abstract
A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
54 Citations
19 Claims
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1. A process for treating biological targets in a fluid of a biological organism, comprising
introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber with an inner diameter of 15 microns to 150 microns for conveying a flow of the fluid, the flow chamber having a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
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16. A process for treating biological targets in a fluid of a biological organism, comprising
introducing an enriched fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
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17. A process for treating cellular targets in a blood sample of a human patient, comprising
introducing a blood sample comprising a cellular target to an assembly that is in fluid communication with a body of the human patient, the assembly comprising an inlet connected to receive the blood sample and an outlet connected to pass the blood sample from the assembly, wherein the assembly comprises a flow chamber with an inner diameter of 15 microns to 150 microns for conveying a flow of the blood sample, the flow chamber having a capture zone comprising a target-specific binding agent, wherein during flow of the blood sample through the flow chamber, the cellular target undergoes flux rolling along the target-specific binding agent.
Specification