Integration of fluids and reagents into self-contained cartridges containing sensor elements
First Claim
1. A system for detecting a plurality of analytes in a sample comprising:
- a sample collection device, wherein the sample collection device is configured to obtain the sample;
a cartridge, wherein the cartridge comprises;
two detection systems disposed within the cartridge comprising(i) a particle-based detection system comprising a supporting member comprising a plurality of cavities formed within the supporting member and having individual particles positioned in individual cavities forming a particle array, and(ii) a membrane-based detection system, wherein the membrane-based detection system comprises a membrane coupled to a body;
wherein the detection systems are configured to interact with at least a portion of the sample flowing through the cartridge to allow concurrent detection of analytes in the sample that is bound by the membrane-based detection system or the particle-based detection system;
a sample reservoir, wherein the sample collection device is configured to deliver the sample to the sample reservoir; and
wherein the sample is substantially contained in the cartridge and collected therein after analysis; and
an optical platform, wherein the optical platform is configured to detect a signal produced by the interaction of the analytes with at least one of the detection systems.
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Accused Products
Abstract
Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator'"'"'s contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
371 Citations
23 Claims
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1. A system for detecting a plurality of analytes in a sample comprising:
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a sample collection device, wherein the sample collection device is configured to obtain the sample; a cartridge, wherein the cartridge comprises; two detection systems disposed within the cartridge comprising (i) a particle-based detection system comprising a supporting member comprising a plurality of cavities formed within the supporting member and having individual particles positioned in individual cavities forming a particle array, and (ii) a membrane-based detection system, wherein the membrane-based detection system comprises a membrane coupled to a body; wherein the detection systems are configured to interact with at least a portion of the sample flowing through the cartridge to allow concurrent detection of analytes in the sample that is bound by the membrane-based detection system or the particle-based detection system; a sample reservoir, wherein the sample collection device is configured to deliver the sample to the sample reservoir; and wherein the sample is substantially contained in the cartridge and collected therein after analysis; and an optical platform, wherein the optical platform is configured to detect a signal produced by the interaction of the analytes with at least one of the detection systems. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification