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Method for inhibiting the activity of mir-155

  • US 8,106,025 B2
  • Filed: 12/31/2008
  • Issued: 01/31/2012
  • Est. Priority Date: 07/31/2003
  • Status: Expired due to Fees
First Claim
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1. A method of inhibiting the activity of a microRNA comprising contacting a cell comprising the microRNA with a compound comprising an oligomeric compound, wherein:

  • the oligomeric compound is at least 90% complementary to miR-155 (SEQ ID NO;

         1062) or a precursor thereof;

    the oligomeric compound consists of 15 to 30 linked monomeric subunits; and

    at least one monomeric subunit is a modified nucleoside.

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