Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
First Claim
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1. A tissue product, comprising a tissue stripped of viable cells wherein the tissue is derived from a tissue of a porcine animal in which at least one allele of an α
- -1,3-galactosyltransferase gene is inactivated and wherein the animal lacks expression of alpha-1,3-galactosyltransferase.
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Abstract
The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3-GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices.
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7 Claims
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1. A tissue product, comprising a tissue stripped of viable cells wherein the tissue is derived from a tissue of a porcine animal in which at least one allele of an α
- -1,3-galactosyltransferase gene is inactivated and wherein the animal lacks expression of alpha-1,3-galactosyltransferase.
- View Dependent Claims (2, 3, 4, 5, 6, 7)
Specification