Noninvasive ocular monitor and method for measuring and analyzing physiological data
First Claim
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1. A non-invasive device for acquiring an ocular image, comprising:
- an optic assembly comprising one or more light sources and a lens;
an imaging system;
a linear activator to focus the optic assembly;
wherein the imaging system acquires an ocular image that is processed to extract one or more ocular features from the ocular image;
wherein a rate of change map is applied, wherein the rate of change map comprises;
(1) for each pixel, determining an average of the sum of the differences of the current pixel or taking a mean difference of the current pixel using a matrix that has the current pixel as the center;
(2) recording this value if this value is above a threshold, otherwise setting this value to 0; and
(3) creating a map with white edges and most of the picture is black;
wherein the one or more ocular features are compared to a standard and used to identify existence of one or more ocular abnormalities, specify a type and extent of the one or more ocular abnormalities, and correlate the type and extent of the one or more ocular abnormalities to a disease state.
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Abstract
A non-invasive device and methods for acquiring and analyzing ocular images from a subject is presented. Aspects of the method comprise of the acquisition of ocular image(s) and subsequent evaluation, classification and/or interpretation of these image(s). The ocular image(s) are acquired using ocular scanning instruments or suitable substitutes. Evaluation, classification, and/or interpretation are most easily accomplished automatically through the use of one or more algorithms.
23 Citations
27 Claims
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1. A non-invasive device for acquiring an ocular image, comprising:
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an optic assembly comprising one or more light sources and a lens; an imaging system; a linear activator to focus the optic assembly; wherein the imaging system acquires an ocular image that is processed to extract one or more ocular features from the ocular image; wherein a rate of change map is applied, wherein the rate of change map comprises;
(1) for each pixel, determining an average of the sum of the differences of the current pixel or taking a mean difference of the current pixel using a matrix that has the current pixel as the center;
(2) recording this value if this value is above a threshold, otherwise setting this value to 0; and
(3) creating a map with white edges and most of the picture is black;wherein the one or more ocular features are compared to a standard and used to identify existence of one or more ocular abnormalities, specify a type and extent of the one or more ocular abnormalities, and correlate the type and extent of the one or more ocular abnormalities to a disease state. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A non-invasive method of diagnosing a disease state, the method comprising:
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accessing an ocular image; applying a rate of change map, wherein the rate of change map comprises;
(1) for each pixel, determining an average of the sum of the differences of the current pixel or taking a mean difference of the current pixel using a matrix that has the current pixel as the center;
(2) recording this value if this value is above a threshold, otherwise setting this value to 0; and
(3) creating a map with white edges and most of the picture is black;processing the ocular image to extract ocular characteristics; classifying the ocular characteristics to determine one or more ocular abnormalities or ocular damage; comparing the one or more ocular abnormalities to a standard; and determining whether the ocular characteristics are abnormal, a type of disease state, and severity of the disease state. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification