Assessing autonomic activity using baroreflex analysis
First Claim
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1. An apparatus capable of being implanted in a patient'"'"'s body, comprising:
- a posture sensor;
a source of blood pressure data;
a heart rate sensor; and
a processor coupled to the posture sensor and the heart rate sensor, the processor configured to;
measure the patient'"'"'s heart rate via the heart rate sensor;
detect a change in a posture of the patient'"'"'s body via the posture sensor; and
determine an autonomic tone of the patient'"'"'s body based on the patient'"'"'s heart rate measured during a time period corresponding to the change in posture;
wherein the processor is configured to determine the autonomic tone by performing a baroreflex sensitivity analysis (BSA) based on the heart rate and blood pressure measured during the time period; and
wherein performing the BSA comprises determining a rate of change of systolic blood pressure relative to heart beat intervals during the time period corresponding to the change in posture.
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Abstract
A method involves implantably detecting changes in posture of a patient'"'"'s body. Baroreflex responses to the posture changes are determined. An autonomic tone of the patient is determined based on the baroreflex responses. Based on the autonomic tone, various patient susceptibilities to disease may be determined, including susceptibilities to heart disease, arrhythmia, and/or sudden cardiac death.
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Citations
20 Claims
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1. An apparatus capable of being implanted in a patient'"'"'s body, comprising:
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a posture sensor; a source of blood pressure data; a heart rate sensor; and a processor coupled to the posture sensor and the heart rate sensor, the processor configured to; measure the patient'"'"'s heart rate via the heart rate sensor; detect a change in a posture of the patient'"'"'s body via the posture sensor; and determine an autonomic tone of the patient'"'"'s body based on the patient'"'"'s heart rate measured during a time period corresponding to the change in posture; wherein the processor is configured to determine the autonomic tone by performing a baroreflex sensitivity analysis (BSA) based on the heart rate and blood pressure measured during the time period; and wherein performing the BSA comprises determining a rate of change of systolic blood pressure relative to heart beat intervals during the time period corresponding to the change in posture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus capable of being implanted in a patient'"'"'s body, comprising:
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a posture sensor; a heart rate sensor; and a processor coupled to the posture sensor and the heart rate sensor, the processor configured to; measure the patient'"'"'s heart rate via the heart rate sensor; detect a change in a posture of the patient'"'"'s body via the posture sensor; and determine an autonomic tone of the patient'"'"'s body based on the patient'"'"'s heart rate measured during a time period corresponding to the change in posture; wherein the processor is configured to determine the autonomic tone by performing a baroreflex sensitivity analysis (BSA) based on the heart rate signals measured during the time period; and wherein the processor is configured to perform the BSA based on a power spectral analysis of heart beat intervals determined via the heart rate sensor.
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15. An apparatus capable of being implanted in a patient'"'"'s body, comprising:
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a posture sensor; a heart rate sensor; and a processor coupled to the posture sensor and the heart rate sensor, the processor configured to; measure the patient'"'"'s heart rate via the heart rate sensor; detect a change in a posture of the patient'"'"'s body via the posture sensor; and determine an autonomic tone of the patient'"'"'s body based on the patient'"'"'s heart rate measured during a time period corresponding to the change in posture; wherein the processor is configured to determine the autonomic tone by performing a baroreflex sensitivity analysis (BSA) based on the heart rate signals measured during the time period; and wherein the processor is configured to perform the BSA based on a time rate of change of heart beat intervals during the time period corresponding to the change in posture. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification