Orifice device having multiple channels and multiple layers for drug delivery

• US 8,109,922 B2
• Filed: 05/27/2004
• Issued: 02/07/2012
• Est. Priority Date: 06/12/2003
• Status: Expired due to Fees

• Current Assignee: Cardinal Health Switzerland 515 GmbH (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Russell, Scott M.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): SCHELL, LAURA C
• Application Number:
  US10/855,141
• Publication Number:
  US 20040267241A1
• Time in Patent Office: 2,812 Days
• Field of Search: 604/93.01, 604/118, 604/246, 604/247, 604/264, 604/523, 604/537, 604/890.1, 604/891.1, 604/891.2, 604/892.1, 604/288.01, 604/288.04, 138/37, 138/42
• US Class Current: 604/891.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: A61M 5/16877 Adjusting flow; Devices for setting a flow rate
• CPC Class Codes: F16K 1/40 of helical shape
• CPC Class Codes: F16K 47/12 the throttling channel being of helical form

Abstract

An orifice device for delivering one or more drugs includes an inner member having a proximal end and a distal end; and a plurality of windings helically wound around the inner member. Each winding defines a separate layer and each winding includes at least one wire helically wound around the inner member. The plurality of windings and the inner member define at least two separate channels for carrying one or more drugs therethrough. An inlet is at the proximal end of each of the plurality of windings and an outlet is at the distal end of the plurality of windings. At least one of the plurality of windings has a plurality of distinct wires helically wound in parallel around the inner member and at least one of the plurality of windings respectively.

Claims

1. An orifice device for delivering one or more drugs comprising:

an inner member having a proximal end and a distal end;

a plurality of windings helically wound around the inner member, each winding defining a separate layer, each winding comprising at least one wire helically wound around the inner member;

the plurality of windings and the inner member defining at least two separate channels for carrying one or more drugs therethrough and an inlet at the proximal end of each of the plurality of windings and an outlet at the distal end of the plurality of windings, and an outer member over the plurality of windings, and an intermediate sleeve defining at least two channels between at least two of the plurality of windings, the intermediate sleeve being tubular with a smooth interior surface and smooth exterior surface from a proximal end of the intermediate sleeve to a distal end of the intermediate sleeve.

2. The orifice device according to claim 1, wherein at least one of the plurality of windings has a plurality of distinct wires helically wound in parallel around the inner member and at least one of the plurality of windings respectively.

3. The orifice device according to claim 2, wherein at least one of the plurality of distinct wires has a circular shape in cross-section.

4. The orifice device according to claim 2, wherein at least one of the plurality of distinct wires has a hexagonal shape in cross-section.

5. The orifice device according to claim 2, wherein at least one of the plurality of distinct wires has an octagonal shape in cross-section.

6. The orifice device according to claim 2, wherein at least one of the plurality of distinct wires has a triangular shape in cross-section.

7. The orifice device according to claim 2, wherein the plurality of distinct wires are made of a degradation-resistant material.

8. The orifice device according to claim 7, wherein the material is a nickel titanium alloy.

9. The orifice device according to claim 7, wherein the material is a stainless steel alloy.

10. The orifice device according to claim 7, wherein the material is plastic.

11. The orifice device according to claim 2, wherein the plurality of distinct wires each have a width ranging from 0.001-0.050 inches.

12. The orifice device according to claim 11, wherein the plurality of distinct wires each have a width ranging from 0.004-0.005 inches.

13. The orifice device according to claim 1, wherein the plurality of windings and the inner member define at least three separate channels for carrying one or more drugs therethrough.

14. The orifice device according to claim 13, wherein at least two of the plurality of distinct wires have a different dimension.

15. The orifice device according to claim 13, wherein at least two of the at least three separate channels deliver one or more drugs at a different fluid flow rate.

16. The orifice device according to claim 13, wherein at least two of the at least three separate channels carry a different drug.

17. The orifice device according to claim 1, wherein at least one of the at least two separate channels deliver one or more drugs at a different fluid flow rate.

18. The orifice device according to claim 1, wherein at least one of the at least two separate channels carry a different drug.

19. The orifice device according to claim 1, wherein the outer member comprises channel filling material for blocking drug flow through one of the at least two separate channels.

20. The orifice device according to claim 19, wherein the channel filling material is a glue.

21. The orifice device according to claim 1, wherein at least one of the outer member and the intermediate member is a sleeve.

22. The orifice device according to claim 1, wherein at least one of the outer member and the intermediate sleeve is made of a polymer material.

23. The orifice device according to claim 22, wherein the polymer material is PTFE.

24. The orifice device according to claim 1, wherein the plurality of windings and the inner member define four separate channels for carrying one or more drugs therethrough.

25. The orifice device according to claim 24, wherein at least one of the four separate channels deliver one or more drugs at a different fluid flow rate.

26. The orifice device according to claim 24, wherein at least one of the four separate channels carries a different drug therethrough.

27. The orifice device according to claim 24, wherein each of the four separate channels deliver one or more drugs at a different fluid flow rate.

28. The orifice device according to claim 27, wherein each of the four separate channels carries a different drug therethrough.

29. The orifice device according to claim 1, wherein the intermediate sleeve is tubular with a constant thickness from a distal end of the intermediate sleeve to a proximal end of the intermediate sleeve.