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Pharmaceutical microparticles

  • US 8,110,224 B2
  • Filed: 07/17/2008
  • Issued: 02/07/2012
  • Est. Priority Date: 03/13/2002
  • Status: Expired due to Fees
First Claim
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1. A process for producing microparticles comprising the steps of:

  • a) dissolving at least one polypeptide in an aqueous buffer to produce an active ingredient solution,b) dissolving a biologically degradable polymer, a water-soluble polymer, and lecithin in an organic solvent to produce a polymer solution containing about 20% lecithin,c) mixing a water-soluble polymer with an aqueous buffer to form an aqueous solution,d) mixing the active ingredient solution of a) and the polymer solution of b) using a gear pump to form an emulsion,e) pumping the emulsion of d) and the aqueous solution of c) with a gear pump to a static mixer and mixing the same in the static mixer to form a water in oil in water emulsion,f) removing the solvent from the emulsion of e), andg) separating the microparticles by filtering and freeze-drying,wherein the microparticles do not exhibit an initial burst release of the therapeutic polypeptide contained therein.

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