Methods of preparing hydrogel coatings

• US 8,110,242 B2
• Filed: 03/22/2007
• Issued: 02/07/2012
• Est. Priority Date: 03/24/2006
• Status: Expired due to Fees

• Current Assignee: Zimmer Incorporated (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Zimmer Incorporated (Zimmer Biomet Holdings, Inc.)
• Inventors: Hawkins, Michael E., Pletcher, Dirk L., Thomas, Brian, Zhang, Kai, Brinkerhuff, Hallie E.
• Primary Examiner(s): Meeks, Timothy
• Assistant Examiner(s): SELLMAN, CACHET I
• Application Number:
  US11/689,754
• Publication Number:
  US 20070225823A1
• Time in Patent Office: 1,783 Days
• Field of Search: 427 21- 224, 427/533, 427/535, 427/536, 427/569, 427/299, 427/307, 427/322, 623/11.11, 623 1611- 1716, 623/18.11, 623 1911- 2376
• US Class Current: 427/2.1
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 2430/24 for joint reconstruction
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: Y10T 428/31536 Including interfacial reaction product of adjacent layers
• CPC Class Codes: Y10T 428/31678 Of metal

Abstract

The present invention provides hydrogel coated, implantable medical devices and methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by physically treating a surface of the medical device, chemically treating the surface, applying a hydrogel precursor and then crosslinking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.

Claims

1. A method of coating an implantable medical device comprising:

physically treating a surface of the device to form physical bonding sites;

chemically treating the surface of the medical device to form chemical bonding sites;

coating the surface with a single type of hydrogel precursor; and

crosslinking the hydrogel precursor to form a hydrogel coating on the surface bonded thereto by the physical and chemical bonding sites, and wherein the surface of the medical device is an articulating surface.

2. The method of claim 1, wherein the surface is a polymer, metal, ceramic, combinations, composites or alloys thereof.

3. The method of claim 1, wherein physically treating the surface comprises at least one of roughening the surface with solid particles, etching the surface, or molding the surface to form a pattern, texture or topography on the surface.

4. The method of claim 1, wherein physically treating the surface comprises roughening the surface with solid particles selected from the group consisting of salts, sugars, sodium bicarbonate, calcium carbonate, aluminum oxide, calcium borate, hydroxyapatite, calcium phosphate, particulate glass, and combinations thereof.

5. The method of claim 1, wherein chemically treating the surface comprises at least one plasma treating the surface;

grafting materials having functional groups onto the surface;

treating the surface with an acid, base or an oxidant;

or combinations thereof.

6. The method of claim 1, wherein chemically treating the surface comprises plasma treating by exposing the surface to plasma gas containing oxygen, nitrogen, argon, ammonia, or combinations thereof.

7. The method of claim 1, further comprising washing the surface with a solvent or a surfactant, or a combination thereof, prior to chemically treating.

8. The method of claim 1, further comprising annealing the physically treated surface prior to coating.

9. The method of claim 1, wherein the coating the surface with the single type of hydrogel precursor further comprises heating the implantable medical device.

10. The method of claim 1, wherein the single type of hydrogel precursor is a polyvinyl alcohol.

11. The method of claim 1, wherein crosslinking the hydrogel precursor comprises radiation crosslinking, physical crosslinking, chemical crosslinking, or combinations thereof.

12. The method of claim 11, wherein crosslinking the hydrogel precursor includes radiation crosslinking by exposing the hydrogel precursor to at least one of ultraviolet radiation, electron beam radiation, gamma radiation, or x-ray radiation.

13. The method of claim 11, wherein crosslinking the hydrogel precursor includes physical crosslinking by exposing the hydrogel precursor to freezing and thawing.

14. The method of claim 11, wherein crosslinking the hydrogel precursor includes chemical crosslinking by exposing the hydrogel precursor to a monoaldehyde or a diisocyanate.