Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
First Claim
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1. A method of inhibiting the activity of a microRNA comprising contacting a cell comprising the microRNA with a compound comprising an oligomeric compound, wherein:
- the oligomeric compound is at least 90% complementary to a miRNA or a precursor thereof;
the oligomeric compound consists of 15 to 30 linked monomeric subunits;
at least one monomeric subunit is a modified nucleoside; and
the miRNA is selected from miR-21 (SEQ ID NO;
64) and miR-1 (SEQ ID NO;
29).
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Abstract
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
76 Citations
25 Claims
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1. A method of inhibiting the activity of a microRNA comprising contacting a cell comprising the microRNA with a compound comprising an oligomeric compound, wherein:
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the oligomeric compound is at least 90% complementary to a miRNA or a precursor thereof; the oligomeric compound consists of 15 to 30 linked monomeric subunits; at least one monomeric subunit is a modified nucleoside; and the miRNA is selected from miR-21 (SEQ ID NO;
64) and miR-1 (SEQ ID NO;
29). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A composition comprising a compound comprising an oligomeric compound, wherein:
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the oligomeric compound is at least 90% complementary to a miRNA or a precursor thereof; the oligomeric compound consists of 15 to 30 linked monomeric subunits; at least one monomeric subunit is a modified nucleoside; and the miRNA is selected from miR-21 (SEQ ID NO;
64) and miR-1 (SEQ ID NO;
29);and a pharmaceutically acceptable diluent or carrier.
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Specification