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Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same

  • US 8,110,651 B2
  • Filed: 01/12/2009
  • Issued: 02/07/2012
  • Est. Priority Date: 01/11/2008
  • Status: Active Grant
First Claim
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1. A heterofunctional polyoxazoline derivative having the general structure:


  • R1

    {[N(COX)CH2CH2]O-[n(COR2)CH2

    CH2)]a}—

    S—

    U—

    Wwherein;

    R1 is an initiating group;

    R2 is an unsubstituted or substituted alkyl, an unsubstituted or substituted alkenyl, an unsubstituted or substituted aralkyl or an unsubstituted or substituted heterocyclylalkyl group;

    U is a linking group;

    X is a pendent moiety containing a first functional group;

    W comprises a moiety bearing a second functional group;

    a is random which indicates a random copolymer or block which indicates a block copolymer;

    o is an integer selected from 1-50;

    n is an integer selected from 0-1000; and

    wherein the first and second functional groups are chemically orthogonal to one another.

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