Peptide fragments for inducing synthesis of extracellular matrix proteins
First Claim
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1. A tetrapeptide capable of inducing production of an extracellular matrix protein, wherein the tetrapeptide comprises SEQ ID NO:
- 3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
8, SEQ ID NO;
25, SEQ ID NO;
27, SEQ ID NO;
30, SEQ ID NO;
40, or SEQ ID NO;
41.
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Abstract
Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
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Citations
24 Claims
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1. A tetrapeptide capable of inducing production of an extracellular matrix protein, wherein the tetrapeptide comprises SEQ ID NO:
- 3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
8, SEQ ID NO;
25, SEQ ID NO;
27, SEQ ID NO;
30, SEQ ID NO;
40, or SEQ ID NO;
41. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24)
- 3, SEQ ID NO;
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15. A tetrapeptide capable of inducing production of an extracellular matrix protein comprising the amino acid sequence PGPR (SEQ ID NO:
- 4).
Specification