Assessing the condition of a joint and devising treatment
First Claim
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1. A method of treating a human joint disease involving cartilage comprising:
- obtaining an electronic volumetric image of a joint, wherein said image includes both normal and diseased cartilage tissue;
creating a three-dimensional model from said image representing at least a portion of a surface of the joint;
electronically evaluating said three-dimensional model to obtain information including volume of at least a portion of the normal cartilage tissue, the diseased cartilage tissue, or both; and
selecting a therapy for treating the joint disease based on said information.
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Abstract
Methods are disclosed for assessing the condition of a cartilage in a joint, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. Information on thickness of cartilage and curvature of cartilage or subchondral bone can be used to plan therapy. Information on movement pattern can be used to plan therapy.
688 Citations
42 Claims
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1. A method of treating a human joint disease involving cartilage comprising:
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obtaining an electronic volumetric image of a joint, wherein said image includes both normal and diseased cartilage tissue; creating a three-dimensional model from said image representing at least a portion of a surface of the joint; electronically evaluating said three-dimensional model to obtain information including volume of at least a portion of the normal cartilage tissue, the diseased cartilage tissue, or both; and selecting a therapy for treating the joint disease based on said information. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of treating a human joint disease involving cartilage comprising:
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obtaining an electronic image of a joint, wherein said image includes both normal and diseased cartilage tissue; creating a three-dimensional model from said image representing at least a portion of a surface of the joint; electronically evaluating said three-dimensional model to obtain volumetric information including a surface area of at least a portion of the normal cartilage tissue, the diseased cartilage tissue, or both; and selecting a therapy for treating the joint disease based on said information. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating a human joint disease involving cartilage comprising:
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obtaining an electronic image of a joint, wherein said image includes both normal and diseased cartilage tissue; creating a three-dimensional model from said image representing at least a portion of a surface of the joint; electronically evaluating said three-dimensional model to obtain information including cartilage thickness using three-dimensional information about at least a portion of the normal cartilage tissue, the diseased cartilage tissue, or both; and selecting a therapy for treating the joint disease based on said information including the cartilage thickness. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of treating a human joint disease involving cartilage comprising:
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obtaining an electronic image of a joint, wherein said image includes both normal and diseased cartilage tissue; creating a three-dimensional model from said image representing at least a portion of a surface of the ioint; electronically evaluating said three-dimensional model to obtain information including three-dimensional curvature of at least a portion of the normal cartilage tissue, the diseased cartilage tissue, or both; and selecting a therapy for treating the joint disease based on said information. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of treating a mammalian joint disease involving cartilage comprising:
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obtaining an electronic volumetric image of a joint, wherein said image includes both normal and diseased cartilage tissue; creating a three-dimensional model from said image representing at least a portion of a surface of the joint; electronically evaluating said three-dimensional model to obtain information including a volume of cartilage loss in a region of a cartilage defect of the cartilage in the joint of a mammal, which includes; determining a thickness, DN, of the normal cartilage near the cartilage defect, obtaining a thickness of the cartilage defect, DD, of the region, subtracting DD from DN to give a thickness of the cartilage loss, DL, and multiplying the DL value times an area of the cartilage defect, AD, to give the volume of cartilage loss, and selecting a therapy for treating the joint disease based on said information. - View Dependent Claims (40, 41, 42)
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Specification