System and method for monitoring cardiac signal activity in patients with nervous system disorders
First Claim
1. A medical device system comprising:
- a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal;
a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and
one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to;
receive the brain signal;
identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period;
receive the cardiac signal and store cardiac signal information in one or more data buffers;
identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period;
calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal but not based on the cardiac signal information corresponding in time to the brain event time period of each of the one or more identified brain events; and
modify an output of the medical device system based upon the Inter-event HRV.
1 Assignment
0 Petitions
Accused Products
Abstract
A medical device system and method for monitoring cardiac signal activity in patients with nervous system disorders. In some embodiments, a brain signal and a cardiac signal are received by a processor, brain events are identified in the brain signal, and the brain events are used to identify portions of the cardiac signal. In some embodiments, Event portions of the cardiac signal are identified corresponding to brain event time periods, and Inter-event portions are identified corresponding to time periods between brain events. An Inter-event heart-rate variability (HRV) calculation is performed using Inter-event portions of the cardiac signal, and an output of the medical device system is modified based upon the calculated Inter-event HRV according to certain embodiments of the invention. An Event HRV may also be calculated according to certain embodiments, and an output modified based on comparisons of the Event HRV to the Inter-event HRV, for example.
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Citations
58 Claims
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1. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal but not based on the cardiac signal information corresponding in time to the brain event time period of each of the one or more identified brain events; and modify an output of the medical device system based upon the Inter-event HRV. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and modify an output of the medical device system based upon the Inter-event HRV, wherein the cardiac signal information includes R-R intervals and the Inter-event HRV is a periodic value representative of variability of the R-R intervals in the inter-event portions of the cardiac signal over a defined period, and wherein the one or more processors are further configured to record a series of the periodic value of the Inter-event HRV to identify a trend. - View Dependent Claims (25, 26, 27, 28)
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29. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and modify an output of the medical device system based upon the Inter-event HRV, wherein the cardiac signal information includes R-R intervals and the Inter-event HRV is a periodic value representative of variability of the R-R intervals in the inter-event portions of the cardiac signal over a defined period, and wherein the one or more processors are configured to modify the output when the periodic value of the Inter-event HRV meets a threshold criterion. - View Dependent Claims (30, 31, 32)
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33. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and modify an output of the medical device system based upon the Inter-event HRV, wherein the cardiac signal information includes R-R intervals and the Inter-event HRV is a periodic value representative of variability of the R-R intervals in the inter-event portions of the cardiac signal over a defined period, and wherein the one or more processors are further configured to calculate an unadjusted HRV based on cardiac signal information stored for both Inter-event and Event portions of the cardiac signal, and wherein the output of the medical device system is modified based upon both the Inter-event HRV and the unadjusted HRV.
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34. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; calculate an Event HRV based on the cardiac signal information corresponding in time to each of the one or more brain event time periods; and modify an output of the medical device system based upon a comparison between the Inter-event HRV and the Event HRV. - View Dependent Claims (35, 36, 37, 38, 39)
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40. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and modify an output of the medical device system based upon the Inter-event HRV, wherein the Inter-event HRV is calculated based on Inter-event portions of the cardiac signal corresponding to sleep periods of the patient, and wherein a sleep sensor is employed to determine the sleep periods of the patient. - View Dependent Claims (41, 42)
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43. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and modify an output of the medical device system based upon the Inter-event HRV, wherein the Inter-event HRV comprises both a day-time and a night-time Inter-event HRV calculated and recorded once every 24 hours.
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44. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal; a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and one or more processors configured to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to; receive the brain signal; identify one or more brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period; receive the cardiac signal and store cardiac signal information in one or more data buffers; identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period; calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and modify an output of the medical device system based upon the Inter-event HRV, wherein the Inter-event HRV is calculated and recorded once every 24 hours, and wherein the one or more processors are further configured to calculate a Therapy HRV based on cardiac signal information corresponding in time to periods of therapy delivery to the patient. - View Dependent Claims (45, 46, 47)
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48. A method of treating a patient, the method comprising:
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receiving a brain signal from the patient; identifying one or more brain events in the brain signal, each of the one or more brain events having a start time and an end time defining a brain event time period for each of the one or more brain events; receiving a cardiac signal from the patient and storing cardiac signal information in one or more data buffers; identifying one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period between two of the one or more brain event time periods; calculating, with processing circuitry, an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal but not based on the cardiac signal information corresponding in time to the brain event time period of each of the one or more identified brain events; and modifying a therapy delivered to the patient based upon the calculated Inter-event HRV. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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Specification