Systems and methods for neuromodulation using pre-recorded waveforms
First Claim
1. A method for neuromodulation to treat a movement disorder, comprising:
- recording an input waveform from a first site in the nervous system in a source subject while the source subject is performing a task, wherein the first site is selected from the group consisting of;
motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus; and
applying an output waveform to a second site in the nervous system in a target subject suffering from the movement disorder while the target subject is performing the same task, wherein the second site is selected from the group consisting of;
motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus;
wherein the output waveform is identical to the input waveform or derived from the input waveform.
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Abstract
Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.
71 Citations
16 Claims
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1. A method for neuromodulation to treat a movement disorder, comprising:
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recording an input waveform from a first site in the nervous system in a source subject while the source subject is performing a task, wherein the first site is selected from the group consisting of;
motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus; andapplying an output waveform to a second site in the nervous system in a target subject suffering from the movement disorder while the target subject is performing the same task, wherein the second site is selected from the group consisting of;
motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus;wherein the output waveform is identical to the input waveform or derived from the input waveform. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for neuromodulation to treat a movement disorder, comprising:
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recording an input waveform from a first site in the nervous system in a source subject, wherein the first site is selected from the group consisting of;
motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus; andapplying an output waveform to a second site in the nervous system in a target subject suffering from the movement disorder, wherein the second site is selected from the group consisting of;
motor cortex, premotor cortex, thalamus, red nucleus, olivary nucleus, and dentate nucleus;wherein the output waveform is identical to the input waveform or derived from the input waveform wherein the second site in the nervous system anatomically corresponds to the first site in the nervous system.
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Specification