RGD peptide attached to bioabsorbable stents

• US 8,114,150 B2
• Filed: 06/14/2006
• Issued: 02/14/2012
• Est. Priority Date: 06/14/2006
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Gale, David C., Huang, Bin, Klaus, Kleine
• Primary Examiner(s): WOODWARD, CHERIE MICHELLE
• Application Number:
  US11/453,679
• Publication Number:
  US 20070293941A1
• Time in Patent Office: 2,071 Days
• Field of Search: None
• US Class Current: 623/1.38
• CPC Class Codes: A61L 31/047 Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

Provided herein is a medical device that includes RGD attached to the device via a spacer compound.

Claims

1. A medical device comprising a chemo-attractant attached to a surface layer of polymer on the medical device, wherein the chemo-attractant is attached to the surface layer through a spacer compound comprising a hydrophobic moiety that comprises a phospholipid and a hydrophilic moiety, and

wherein the chemo-attractant is attached to the hydrophilic moiety of the spacer compound and the hydrophobic moiety of the spacer compound is grafted to or embedded within the surface layer of polymer on the medical device such that upon deployment of the medical device, the hydrophilic moiety of the spacer compound projects from the surface layer of polymer.

2. The medical device of claim 1, wherein the hydrophilic moiety of the spacer compound comprises poly(ethylene glycol) (PEG).

3. The medical device of claim 1, wherein the phospholipid comprises distearoylphosphatidylethanolamine (DSPE) or 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE).

4. The medical device of claim 3, wherein spacer compound is DMPE-PEG.

5. The medical device of claim 1, wherein spacer compound is a di-block copolymer,

wherein the hydrophobic moiety comprises a hydrophobic polymer block, and

wherein the hydrophilic moiety comprises a hydrophilic polymer block.

6. The medical device of claim 5, wherein the hydrophobic polymer block comprises poly(lactic acid).

7. The medical device of claim 5, wherein the hydrophilic polymer block comprises PEG, poly(alkylene oxide), poly(vinyl alcohol) or combinations of these.

8. The medical device of claim 5, wherein the spacer compound is poly(L-lactide-co-PEG (3000)).

9. The medical device of claim 1, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

10. The medical device of claim 2, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

11. The medical device of claim 3, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

12. The medical device of claim 4, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

13. The medical device of claim 5, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

14. The medical device of claim 6, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

15. The medical device of claim 7, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

16. The medical device of claim 8, wherein the chemo-attractant comprises RGD, cRGD, mimetics thereof, or combinations of these.

17. The medical device of claim 9, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

18. The medical device of claim 10, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

19. The medical device of claim 11, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

20. The medical device of claim 12, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

21. The medical device of claim 13, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

22. The medical device of claim 14, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

23. The medical device of claim 15, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

24. The medical device of claim 16, wherein the chemo-attractant comprises cRGD, cRGD mimetics, or combinations of these.

25. The medical device of claim 1, wherein the medical device is a bioabsorbable stent.

26. The medical device of claim 9, wherein the medical device is a bioabsorbable stent.

27. The medical device of claim 12, wherein the medical device is a bioabsorbable stent.

28. The medical device of claim 16, wherein the medical device is a bioabsorbable stent.