Stent coating
First Claim
1. An expandable intraluminal graft for use within a body passageway including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said body member having a first cross-sectional shape having a first cross-sectional area which permits intraluminal delivery of said body member into the body cavity, and a second expanded cross-sectional shape having a second cross-sectional area which is greater than said first cross-sectional area, said biological agent at least partially secured to said body member, said biological agent including one or more agents selected from the group consisting of Trapidil, GM-CSF, Trapidil derivative and GM-CSF derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including one or more compounds selected from the group consisting of a polymer and copolymer, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, between said body member and said intermediate compound, or combinations thereof, said intermediate compound at least partially delays delivery of said biological agent into said body passageway, said biological agent is at least partially releasably coated on said graft, said intermediate compound having a coating thickness of about 5,000 to 250,000 Å
- , said biological agent present in an amount of at least 1 μ
g and up to about 10 mg.
3 Assignments
0 Petitions
Accused Products
Abstract
An expandable stent for use within a body passageway having a body member with two ends and a wall surface disposed between the ends. The body member has a first diameter to permit delivery of the body member into a body passageway and a second expanded diameter. The surface of the stent is coated with a biological agent and a polymer which controls the release of the biological agent.
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Citations
22 Claims
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1. An expandable intraluminal graft for use within a body passageway including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said body member having a first cross-sectional shape having a first cross-sectional area which permits intraluminal delivery of said body member into the body cavity, and a second expanded cross-sectional shape having a second cross-sectional area which is greater than said first cross-sectional area, said biological agent at least partially secured to said body member, said biological agent including one or more agents selected from the group consisting of Trapidil, GM-CSF, Trapidil derivative and GM-CSF derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including one or more compounds selected from the group consisting of a polymer and copolymer, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, between said body member and said intermediate compound, or combinations thereof, said intermediate compound at least partially delays delivery of said biological agent into said body passageway, said biological agent is at least partially releasably coated on said graft, said intermediate compound having a coating thickness of about 5,000 to 250,000 Å
- , said biological agent present in an amount of at least 1 μ
g and up to about 10 mg. - View Dependent Claims (2, 3, 4, 5)
- , said biological agent present in an amount of at least 1 μ
- 6. A graft for use in repairing a body passageway, said graft including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said biological agent at least partially secured to said body member, said biological agent including two or more agents selected form the group consisting of Trapidil, GM-CSF, Trapidil derivative, and GM-CSF derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including one or more compounds selected from the group consisting of parylene and parylene derivative, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, at least partially encapsulating at least a portion of said biological agent between said body member and said intermediate compound, or combinations thereof.
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11. A graft for use in repairing a body passageway, said graft including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said biological agent at least partially secured to said body member, said biological agent including a first compound selected from the group consisting of Trapidil, GM-CSF, Trapidil derivative and GM-CSF derivative and a second compound selected form the group consisting of paclitaxel, rapamycin, paclitaxel derivative and rapamycin derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including one or more compounds selected from the group consisting of parylene and parylene derivative, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, at least partially encapsulating at least a portion of said biological agent between said body member and said intermediate compound, or combinations thereof, said intermediate compound at least partially delays delivery of said biological agent into said body passageway, said biological agent is at least partially releasably coated on said graft, said intermediate compound having a coating thickness of about 5,000 to 250,000 Å
- , said biological agent present in an amount of at least 1 μ
g and up to about 10 mg. - View Dependent Claims (12, 13, 14)
- , said biological agent present in an amount of at least 1 μ
- 15. A graft for use in repairing a body passageway, said graft including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said biological agent at least partially secured to said body member, said biological agent including a first compound selected from the group consisting of Trapidil, GM-CSF, Trapidil derivative and GM-CSF derivative and a second compound selected from the group consisting of paclitaxel, rapamycin, paclitaxel derivative and rapamycin derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including one or more compounds selected from the group consisting of parylene and parylene derivative, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, at least partially encapsulating at least a portion of said biological agent between said body member and said intermediate compound, or combinations thereof, said biological agent includes Trapidil, Trapidil derivative, and mixtures thereof, said biological agent includes GM-CSF, GM-CSF derivative, and mixtures thereof.
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17. A graft for use in repairing a body passageway, said graft including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said biological agent at least partially secured to said body member, said biological agent including a first compound selected from the group consisting of Trapidil, Trapidil derivative, or mixtures thereof and a second compound selected form the group consisting of GM-CSF, GM-CSF derivative, paclitaxel, paclitaxel derivative, rapamycin and rapamycin derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including parylene, parylene derivative or mixtures thereof, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, at least partially encapsulating at least a portion of said biological agent between said body member and said intermediate compound, or combinations thereof, said intermediate compound at least partially delays delivery of said biological agent into said body passageway, said biological agent is at least partially releasably coated on said graft, said intermediate compound having a coating thickness of about 5,000 to 250,000 Å
- , said biological agent present in an amount of at least 1 μ
g and up to about 10 mg. - View Dependent Claims (18, 19, 20)
- , said biological agent present in an amount of at least 1 μ
- 21. A graft for use in repairing a body passageway, said graft including a body member, intermediate compound, and biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said biological agent at least partially secured to said body member, said biological agent including a first compound selected from the group consisting of Trapidil, Trapidil derivative, or mixtures thereof and a second compound selected from h group consisting of GM-CSF, GM-CSF derivative, paclitaxel, paclitaxel derivative, rapamycin and rapamycin derivative, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including parylene, parylene derivative or mixtures thereof, said intermediate compound at least partially encapsulating at least a portion of said biological agent in said intermediate compound, at least partially encapsulating at least a portion of said biological agent between said body member and said intermediate compound, or combinations thereof, said second compound includes GM-CSF, GM-CSF derivative, and mixtures thereof.
Specification