Composition for treating dry eye and related methods of manufacture and methods of use

• US 8,114,420 B2
• Filed: 03/28/2006
• Issued: 02/14/2012
• Est. Priority Date: 03/31/2005
• Status: Active Grant

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Xia, Erning, Salamone, Joseph, Liu, X. Michael
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): HUANG, GIGI GEORGIANA
• Application Number:
  US11/391,056
• Publication Number:
  US 20060222623A1
• Time in Patent Office: 2,149 Days
• Field of Search: 424/400
• US Class Current: 424/400
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 31/737 Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate A61K31/727 takes precedence
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.

Claims

1. A dry eye composition comprising an aqueous solution that comprises carboxy-containing polymer at a concentration from about 1 to about 1.75 percent by weight of the solution, and a single polyol at a concentration of 2, 3, or 4 percent by weight of the solution, wherein the carboxy-containing polymer has a molecular weight in a range from 90 kDa to 700 kDa, the carboxy-containing polymer comprises carboxy-containing cellulose, and the carboxy-containing polymer has a degree of substitution value in a range from 0.25 to 1, and wherein the polyol contains 2 to 6 carbon atoms.

2. The dry eye composition of claim 1, wherein the polyol contains 2 to 4 carbon atoms.

3. The dry eye composition of claim 1, wherein the polyol is glycerin.

4. The composition of claim 1, wherein the carboxy-containing polymer is carboxyethyl cellulose.

5. The composition of claim 1, wherein the polyol is selected from the group consisting of glycerin, ethylene glycol, propylene glycol, sorbitol, mannitol and monosaccharides.