Solvent/polymer solutions as suspension vehicles
First Claim
1. A stable, nonaqueous suspension formulation, comprising:
- a particle formulation comprising an active agent, wherein the active agent comprises a peptide, polypeptide, or protein, and the particle formulation further comprises a sugar, methionine, and a buffer; and
a nonaqueous, single-phase vehicle consisting essentially of about 40% to 60% (w/w) polyvinylpyrrolidone and about 40% to 60% (w/w) benzyl benzoate, wherein the vehicle has a viscosity of between approximately 5,000 poise to approximately 50,000 poise.
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Accused Products
Abstract
A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
128 Citations
17 Claims
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1. A stable, nonaqueous suspension formulation, comprising:
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a particle formulation comprising an active agent, wherein the active agent comprises a peptide, polypeptide, or protein, and the particle formulation further comprises a sugar, methionine, and a buffer; and a nonaqueous, single-phase vehicle consisting essentially of about 40% to 60% (w/w) polyvinylpyrrolidone and about 40% to 60% (w/w) benzyl benzoate, wherein the vehicle has a viscosity of between approximately 5,000 poise to approximately 50,000 poise. - View Dependent Claims (2, 3, 4, 6, 7, 8, 9, 10)
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5. The suspension formulation of claim , wherein the sugar is sucrose, and the buffer is citrate.
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11. A stable, nonaqueous suspension formulation, comprising:
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a particle formulation comprising (i) a peptide, polypeptide, or protein, (ii) sucrose, (iii) methionine, and (iv) citrate buffer; and a nonaqueous, single-phase vehicle consisting essentially of about 40% to 60% (w/w) polyvinylpyrrolidone and about 40% to 60% (w/w) benzyl benzoate, wherein the vehicle has a viscosity of between approximately 5,000 poise to approximately 50,000 poise. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification