Methods and compositions for the treatment of Parkinson's Disease

• US 8,114,892 B2
• Filed: 02/15/2007
• Issued: 02/14/2012
• Est. Priority Date: 02/16/2006
• Status: Expired due to Fees

• Current Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Original Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Inventors: Kim, Deog Joong, Kim, Chun Hyung, Kim, Kwang Soo
• Primary Examiner(s): Hill, Kevin K.
• Application Number:
  US12/279,473
• Publication Number:
  US 20090226401A1
• Time in Patent Office: 1,825 Days
• Field of Search: 514/4.6, 514/17.7, 514/18.2, 514/311
• US Class Current: 514/311
• CPC Class Codes: A61K 31/4706 4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 33/06 Antimalarials

Abstract

The invention features methods and kits for treating or inhibiting the development of Parkinson'"'"'s Disease by administering 7-chloro-4-aminoquinoline compounds, e.g., amodiaquine or glafenine. Stem cells are also useful in the methods of the invention and may be administered separately from or together with 7-chloro-4-aminoquinoline compounds. The invention further features methods of identifying additional chemical compounds that are useful in the treatment or inhibition of the development of Parkinson'"'"'s Disease.

Claims

1. A method for treating or inhibiting the development of Parkinson'"'"'s Disease comprising the steps of:

(a) determining whether a patient has or is at risk of developing Parkinson'"'"'s Disease; and

(b) if said patient has or is at risk of developing Parkinson'"'"'s Disease, administering to said patient a pharmaceutical composition comprising amodiaquine in an amount sufficient to treat or inhibit the development of Parkinson'"'"'s Disease and a pharmaceutically acceptable excipient.