Crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride
First Claim
Patent Images
1. A crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride or a hydrate thereof containing up to and including 1.6% water having an X-ray diffraction pattern which comprises the following peaks:
- 6.8±
0.1, 10.9±
0.1, 14.2±
0.1 and 16.6±
0.1°
in 2θ
;
when the pattern is obtained from a copper radiation source (CuKα
;
λ
=1.54056 Å
).
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-yl-methyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride salt, a pharmaceutical formulation containing said salt and to methods for treating cancer and for inhibiting tumor growth using said salt.
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Citations
2 Claims
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1. A crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride or a hydrate thereof containing up to and including 1.6% water having an X-ray diffraction pattern which comprises the following peaks:
- 6.8±
0.1, 10.9±
0.1, 14.2±
0.1 and 16.6±
0.1°
in 2θ
;
when the pattern is obtained from a copper radiation source (CuKα
;
λ
=1.54056 Å
). - View Dependent Claims (2)
- 6.8±
Specification
-
- Resources
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Current AssigneeDenovo Biopharma LLC
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Original AssigneeEli Lilly and Company
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InventorsBush, Julie Kay, Faul, Margaret Mary, Reutzel-Edens, Susan Marie
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Primary Examiner(s)QAZI, SABIHA NAIM
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Application NumberUS10/520,360Publication NumberTime in Patent Office3,143 DaysField of Search540/479, 546/94, 546/201, 546/466, 514/414, 548/455, 548/466, 548/468US Class Current514/414CPC Class CodesA61P 35/00 Antineoplastic agentsA61P 43/00 Drugs for specific purposes...C07D 401/14 containing three or more he...
