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Bronchodilating β-agonist compositions and methods

  • US 8,114,912 B2
  • Filed: 05/24/2010
  • Issued: 02/14/2012
  • Est. Priority Date: 07/10/2003
  • Status: Active Grant
First Claim
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1. A kit comprising:

  • (a) a propellant-free, sterile unit dose package about 0.1 to about 3.0 mL of a pharmaceutical composition comprising (R) formoterol or a salt thereof at a concentration of from about 0.08 μ

    g/mL to about 43 μ

    g/mL based on formoterol free base, in a pharmacologically suitable solution, wherein the composition further comprises water and a buffer having a concentration of from about 1 mM to about 50 mM, said composition having a pH of about 4.0 to about 6.0, and having an estimated shelf life of greater than 90% after 3 months storage at 25°

    C. and after 3 years storage at 5°

    C.; and

    (b) a nebulizer.

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