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Di-alpha amino anthraquinone compositions

  • US 8,114,979 B2
  • Filed: 08/10/2010
  • Issued: 02/14/2012
  • Est. Priority Date: 09/20/2002
  • Status: Active Grant
First Claim
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1. A compound comprising an oligonucleotide labeled with a fluorophore and quencher, wherein the oligonucleotide is adapted to hybridize to a selected nucleic acid sequence, and wherein the quencher is a di-alpha amino anthraquinone comprising a first amino group and a second amino group attached at alpha-positions of the anthraquinone, wherein fluorescence of the fluorophore is reduced by fluorescence resonance energy transfer to the quencher or by ground state quenching by the quencher when the oligonucleotide is not hybridized to the selected nucleic acid sequence.

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