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Method of calibrating of an analyte-measurement device, and associated methods, devices and systems

  • US 8,116,840 B2
  • Filed: 10/30/2007
  • Issued: 02/14/2012
  • Est. Priority Date: 10/31/2003
  • Status: Active Grant
First Claim
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1. An in vivo analyte sensor calibration system, comprising:

  • an in vivo analyte sensor, at least a portion of the sensor subcutaneously positioned to generate one or more signals;

    a calibration sensor configured to be placed in contact with a blood sample from an off-finger calibration site to provide a calibration measurement; and

    a calibration device in signal communication with one or more of the in vivo analyte sensor or the calibration sensor to calibrate the in vivo analyte sensor by determining whether a quality of the calibration measurement is suitable for calibration, and converting the one or more signals from the in vivo analyte sensor into a corresponding one or more analyte concentration values using the calibration measurement if the quality of the calibration measurement is determined to be suitable;

    wherein the calibration device is configured to determine a temperature compensated analyte concentration value based at least in part on the one or more analyte concentration values and a temperature compensation factor;

    wherein the calibration device is further configured to determine a lag compensated analyte concentration value by applying a lag factor to a change in the temperature compensated analyte value over a time period between two acceptable calibration points divided by the time period between the two acceptable calibration points added to the temperature compensated analyte value; and

    wherein the two acceptable calibration points is deemed acceptable based on at least one evaluation standard being met.

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