Transdermal porator and patch system and method for using same
First Claim
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1. A transdermal permeant delivery system for delivery of at least one permeant into a tissue membrane of a subject, comprising:
- a disposable substrate having an upper substrate surface and defining a poration area;
a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; and
a patch that is selectively removable from the top surface of the first release liner, comprising;
a backing layer having an upper surface and an opposed lower surface; and
a reservoir mounted thereon a portion of the lower surface of the backing layer and configured for releaseably containing the at least one permeant;
wherein, in a connected position, a first portion of the backing layer is releaseably mounted thereto the top surface of the first release liner in spaced registration with the poration area of the substrate, and wherein, in the connected position, a second portion of the backing layer is folded back into a folded position, in which the lower surface of the second portion of the backing layer faces outwardly away from the upper substrate surface of the substrate.
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Abstract
A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
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Citations
92 Claims
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1. A transdermal permeant delivery system for delivery of at least one permeant into a tissue membrane of a subject, comprising:
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a disposable substrate having an upper substrate surface and defining a poration area; a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; and a patch that is selectively removable from the top surface of the first release liner, comprising; a backing layer having an upper surface and an opposed lower surface; and a reservoir mounted thereon a portion of the lower surface of the backing layer and configured for releaseably containing the at least one permeant; wherein, in a connected position, a first portion of the backing layer is releaseably mounted thereto the top surface of the first release liner in spaced registration with the poration area of the substrate, and wherein, in the connected position, a second portion of the backing layer is folded back into a folded position, in which the lower surface of the second portion of the backing layer faces outwardly away from the upper substrate surface of the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A transdermal permeant delivery system comprising:
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a disposable substrate having an upper substrate surface and defining a poration area, the disposable substrate comprising a filament array having a plurality of filaments that are disposed in the poration area, wherein each filament is configured for forming a micropore in the tissue membrane; a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; and a patch that is selectively removable from the top surface of the first release liner, comprising; a backing layer having an upper surface and an opposed lower surface; and a reservoir mounted thereon a portion of the lower surface of the backing layer and configured for releaseably containing at least one permeant; wherein, in a connected position, a first portion of the backing layer is releaseably mounted thereto the top surface of the first release liner in spaced registration with the poration area of the substrate, and wherein, in the connected position, a second portion of the backing layer is folded back into a folded position, in which the lower surface of the second portion of the backing layer faces outwardly away from the upper substrate surface of the substrate. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79)
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80. A transdermal permeant delivery system comprising:
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a disposable substrate having an upper substrate surface and defining a poration area, the disposable substrate comprising a filament array having a plurality of filaments that are disposed in the poration area, wherein each filament is configured for forming a micropore in the tissue membrane; a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; and a patch that is selectively removable from the top surface of the first release liner, comprising; a backing layer having an upper surface and an opposed lower surface; and a reservoir mounted thereon a portion of the lower surface of the backing layer and configured for releaseably containing at least one permeant; wherein, in a connected position, at least a portion of the backing layer of the patch is releaseably mounted thereto the top surface of the first release liner in spaced registration with the poration area of the substrate. - View Dependent Claims (81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92)
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Specification