Measurement of patient physiological parameters
First Claim
1. A method of determining a physiological parameter of a patient, comprising:
- applying a measurement signal through a plurality of electrodes implanted in contact with a wall of a blood vessel of the patient, the measurement signal having a known parameter;
obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter;
calculating impedance of the blood vessel based on the measurement signal and the resultant signal; and
determining a physiological parameter based on the impedance of the blood vessel.
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Accused Products
Abstract
A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.
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Citations
24 Claims
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1. A method of determining a physiological parameter of a patient, comprising:
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applying a measurement signal through a plurality of electrodes implanted in contact with a wall of a blood vessel of the patient, the measurement signal having a known parameter; obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter; calculating impedance of the blood vessel based on the measurement signal and the resultant signal; and determining a physiological parameter based on the impedance of the blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system, comprising:
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at least one pair of electrodes adapted to be implanted in contact with a wall of blood vessel of a patient; and a controller communicably coupled to the pair of electrodes, the controller configured to calculate the impedance of the blood vessel based on a measured signal from the pair of electrodes, and determine a physiological parameter of a patient based on the calculated impedance. - View Dependent Claims (10, 11, 12, 13)
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14. An implantable baroreflex therapy system for providing real-time feedback of physiological parameters comprising:
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an implantable baroreflex modulation device including one or more therapy electrodes adapted to be positioned implanted in contact with a wall of a blood vessel, the baroreflex modulation device configured to electrically activate a baroreceptor; and a control system operably coupled to the baroreflex modulation device, the control system configured to transmit a therapy signal having a known parameter to the baroreflex modulation device, wherein the one or more therapy electrodes are configured to monitor a resultant signal indicative of a parameter that correlates to the known parameter of the therapy signal, the control system being configured to calculate the impedance of the blood vessel based on the known parameter and the resultant parameter, determine one or more patient physiological parameters based on the calculated impedance, and modify the therapy signal based on the one or more patient physiological parameters. - View Dependent Claims (15, 16, 17, 18, 19)
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20. A method of providing therapy having real-time feedback, comprising:
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providing a baroreflex modulation device including a therapy electrode, the baroreflex modulation device configured to electrically activate a baroreceptor; providing one or more measurement electrodes; providing instructions, comprising; implanting the baroreflex modulation device proximate a blood vessel; implanting the one or more measurement electrodes in contact with a wall of the blood vessel; transmitting a therapy signal from a control system to the therapy electrode of the baroreflex modulation device, the therapy signal having at least one known parameter; monitoring a resultant signal with the one or more measurement electrodes, the resultant signal having a resultant parameter; calculating the impedance of the blood vessel based on the known parameter and the resultant parameter; determining one or more physiological parameters based on the impedance of the blood vessel; and adjusting the therapy signal based on the one or more physiological parameters. - View Dependent Claims (21, 22)
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23. A method, comprising:
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providing a baroreflex modulation device including two or more electrodes, the baroreflex modulation device configured to electrically activate a baroreceptor; providing a control system operably coupled to the baroreflex modulation device; and providing instructions recorded on a tangible medium on how to provide real-time feedback of a physiological parameter of a patient undergoing baroreflex therapy, the instructions including; implanting the baroreflex modulation device such that the two or more electrodes are in contact with a wall of a blood vessel; delivering a therapy signal having a known parameter to at least one of the two or more electrodes; monitoring with the at least one of the two or more electrodes a resultant signal having a resultant parameter as the therapy signal is being delivered; calculating with the control system an impedance of the blood vessel based on the known parameter and the resultant parameter; determining one or more patient parameters based on the calculated impedance; and modifying the therapy signal based on the one or more patient parameters.
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24. A kit for a baroreflex therapy system, comprising:
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a baroreflex modulation device including two or more electrodes, the baroreflex modulation device configured to electrically activate a baroreceptor; a control system operably coupleable to the baroreflex modulation device; and instructions recorded on a non-transitory tangible medium for operating the system so as to provide real-time feedback of a physiological parameter of a patient undergoing baroreflex therapy, the instructions including; instructions to program the control system to deliver a therapy signal having a known parameter to the patient through at least one of the two or more electrodes of the baroreflex modulation device and to cause the control system to monitor with at least one of the two or more electrodes a resultant signal having a resultant parameter, calculating with the control system an impedance of the blood vessel based on the known parameter and the resultant parameter, determining one or more patient parameters based on the calculated impedance, and modifying the therapy signal based on the one or more patient parameters.
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Specification