Method of making an electrochemical sensor
First Claim
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1. A method of manufacturing a sensor for the in vitro determination of the presence and/or level of glucose in a sample, the method comprising:
- disposing a conductive material on a substrate to provide one or more traces, at least one trace having a width of about 25 microns to 250 microns; and
forming a sample chamber in the substrate so that the sensor can determine the presence and/or level of glucose in a volume of sample of about 1 microliter or less in the sample chamber.
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Abstract
A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.
340 Citations
30 Claims
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1. A method of manufacturing a sensor for the in vitro determination of the presence and/or level of glucose in a sample, the method comprising:
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disposing a conductive material on a substrate to provide one or more traces, at least one trace having a width of about 25 microns to 250 microns; and forming a sample chamber in the substrate so that the sensor can determine the presence and/or level of glucose in a volume of sample of about 1 microliter or less in the sample chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of manufacturing a sensor for the in vitro determination of the presence and/or level of glucose in a sample, the method comprising:
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providing a substrate; disposing a conductive material on the substrate to provide one or more traces, at least one trace having a width of about 25 microns to 250 microns; and forming a sample chamber in the substrate to a volume of sample of about 1 microliter or less, the one or more traces configured to be in fluid contact with the volume of sample received in the formed sample chamber to determine the level of glucose in the volume of sample. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. A method of manufacturing an in vitro sensor for the determination of the presence and/or level of glucose in a sample, the method comprising:
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providing a substrate; disposing a conductive material on the substrate to provide one or more traces, at least one trace having a width of about 25 microns to 250 microns; and forming a sample chamber in the substrate to define the in vitro sensor, wherein the presence and/or the level of glucose is determined with a volume of sample of about 1 microliter or less withdrawn from a subject and received in the formed sample chamber in the substrate of the in vitro sensor. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification