Nanopatterned surfaces and related methods for selective adhesion, sensing and separation
First Claim
1. A method of using a spatial surface configuration for selective particle interaction, said method comprising:
- providing a heterogeneous surface comprising a surface member and a plurality of components thereon, said components spaced about said surface member and having a density thereon, said surface heterogeneity providing different interactions of said surface member and said spaced components with a particle exposed thereto;
exposing a particle to said heterogeneous surface; and
sensing at least one of physical and chemical interaction of said particle with said heterogeneous surface, said interaction selective for said particle.
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Abstract
The invention is comprised, in part, of a surface that contains more than one component or construct. Such heterogenous surface compositions and configurations, related systems and methods for sensing particle or analyte interaction therewith can selectively and/or differentially interact with a range of particles/analytes, in lieu of specific molecular sensor-analyte interactions for each particle. These interactions of various analytes or particles can differ sufficiently in strength and range between multiple analyte types or particles to effect a separation of analytes or particles mixtures, in a way that requires no sensing or detection. With incorporation of a sensing mechanism, discrimination/detection of different compounds within an analyte mixture can be accomplished.
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Citations
28 Claims
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1. A method of using a spatial surface configuration for selective particle interaction, said method comprising:
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providing a heterogeneous surface comprising a surface member and a plurality of components thereon, said components spaced about said surface member and having a density thereon, said surface heterogeneity providing different interactions of said surface member and said spaced components with a particle exposed thereto; exposing a particle to said heterogeneous surface; and sensing at least one of physical and chemical interaction of said particle with said heterogeneous surface, said interaction selective for said particle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for particle sensing, said method comprising:
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providing a heterogeneous surface comprising a charged surface member and a plurality of nanodimensioned protein components thereon, said protein components spaced about said surface and having a density thereon, each said protein component comprising a net charge; exposing a particle to said heterogeneous surface, said particle comprising a net charge; and sensing interaction of said particle with said heterogeneous surface. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification