Method and apparatus for prediction and warning of hypoglycaemic attack

• US 8,118,741 B2
• Filed: 11/21/2005
• Issued: 02/21/2012
• Est. Priority Date: 12/20/2004
• Status: Active Grant

• Current Assignee: T&W Engineering A/S (WS Audiology A/S)
• Original Assignee: Hypo-Safe A/X
• Inventors: Beck-Nielsen, Henning
• Primary Examiner(s): Le, Miranda
• Assistant Examiner(s): TOTH, KAREN E
• Application Number:
  US11/793,271
• Publication Number:
  US 20090062678A1
• Time in Patent Office: 2,283 Days
• Field of Search: 600/347, 600/365, 600/544, 600/545
• US Class Current: 600/365
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00

Abstract

The present invention includes a method and device for warning of hypoglycaemic attacks, which is a big problem for especially diabetics, who are in insulin treatment. It is estimated that about 1 million people have a decreased quality of life as a result of hypoglycaemic attacks. The invention collects EEG signals from people, who must be supervised and analyses these in order to detect characteristic changes in the EEG signals, which occurs in advance of a hypoglycaemic attack. In a preferred embodiment the EEG signals are collected with subcutaneously placed electrodes and the signals are lead via wires drawn under the person'"'"'s skin to a similar subcutaneously placed signal processing unit. The signal processing analyses the EEG signals and when the pre-seizure characteristics signal changes are detected, a warning signal is given to the person from an alarm giver build into the signal processing unit, e.g. in form of a vibrator. When a person detects a warning signal, the person can prevent the hypoglycaemic attack by e.g. consuming a sugary food.

Claims

1. Method for warning of imminent hypoglycaemic attacks for people such as diabetics characterized in that the warning is based on analysis of one or more electroencephalographic (EEG) signals from a person without the use of electrocardiographic (ECG) signals, said method comprising:

providing said person with a portable hypoglycaemic attack warning system comprising an interface unit implanted below the person'"'"'s skin and an externally worn unit, said implanted interface unit having connected thereto implanted EEG signal gathering electrodes and further comprising a wireless signal transmitter, said externally worn unit comprising a signal processing unit for wirelessly receiving signals transmitted by the interface unit and for performing analysis of said signals for identifying characteristics therein indicative of an imminent hypoglycaemic attack;

wirelessly receiving transmitted EEG signals in said signal processing unit and performing analysis of said signals therein so as to detect an imminent hypoglycaemic attack and

giving a warning to said person that a said attack is determined to be imminent.

2. Method for warning of hypoglycaemic attacks according to claim 1 characterized in that the warning is given after signal analytic identification of pre-seizure characteristic EEG changes which include at least one of decrease in frequency and increase in amplitude.

3. Method for warning of hypoglycaemic attacks according to claim 1 characterized in that the EEG signals are registered from two or more said electrodes placed intracranially or subcutaneously.

4. Method for warning of hypoglycaemic attacks according to claim 3 characterized in that that the EEG signals from the electrodes are transmitted via subcutaneously drawn wires to a subcutaneous placed said signal interface unit.

5. Method for warning of hypoglycaemic attacks according to claim 1 characterized in that the EEG signals in advance of the signal analysis are filtered through band-pass filtering.

6. Method for warning of hypoglycaemic attacks according to claim 1 characterized in that the signal analysis of the EEG signal is carried out in the time- or frequency domain.

7. Method for warning of hypoglycaemic attacks according to claim 1 characterized in that the pre-seizure characteristic EEG signal changes are detected by application of signal analysis based on algorithms such as Baye'"'"'s methods including bayesian classifier, logistic regression or neutral network.

8. A method as claimed in claim 7, wherein the pre-seizure characteristic EEG signal changes are detected by application of signal analysis based on an algorithm which is continuously adapted to the person.

9. A hypoglycaemic attack warning device for warning of imminent hypoglycaemic attacks for people such as diabetics comprising an interface unit to be implanted below a person'"'"'s skin and an externally worn unit, said interface unit having connected thereto electroencephalographic (EEG) signals gathering electrodes suitable for implantation in the body of the person person and further comprising a wireless signal transmitter, said externally worn unit comprising a signal processing unit for wirelessly receiving signals transmitted by the interface unit and for performing analysis of said signals without using electrocardiographic (ECG) signals for identifying characteristics therein indicative of an imminent hypoglycaemic attack and further comprising means for giving a warning to said person when a said attack is determined to be imminent.

10. Method for warning a person of imminent hypoglycaemic attacks characterized in that the warning is based on analysis of one or more electroencephalographic (EEG) signals from the person without the use of electrocardiographic (ECG) signals, said method comprising:

providing said person with a portable hypoglycaemic attack warning system comprising an interface unit implanted below the person'"'"'s skin and an externally worn unit, said implanted interface unit having connected thereto implanted electrodes for gathering EEG signals, said externally worn unit comprising a signal processing unit for wirelessly receiving said EEG signals;

wirelessly receiving said EEG signals in said signal processing unit and performing analysis of said signals therein so as to detect an imminent hypoglycaemic attack; and

providing a warning to said person that said attack is determined to be imminent.