Devices and methods for accelerometer-based characterization of cardiac function and identification of LV target pacing zones
First Claim
1. A device for monitoring cardiac function, comprising:
- a. a single multi-axis acceleration sensor configured for disposition within the coronary sinus;
b. wherein the acceleration sensor is configured to characterize left ventricular function by simultaneously monitoring both cardiac vibration corresponding to mitral regurgitation and left ventricular longitudinal displacement motion;
c. a circuit implemented in hardware or software, or both, for receiving signals indicative of left ventricular function including signals corresponding to cardiac vibration caused by mitral regurgitation and signals corresponding to left ventricular longitudinal displacement motion, the circuit further mathematically singly integrating the received signals to obtain velocity information about left ventricular function and the circuit further mathematically doubly integrating the received signals to obtain displacement information about left ventricular function, wherein the single and double integrations are performed using only data from the single multi-axis acceleration sensor.
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Abstract
Systems according to the invention employ an acceleration sensor to characterize displacement and vibrational LV motion, and uses this motion data to characterize the different phases of the LV cycle for analyzing LV function. Systems may identify a target pacing region or regions in the LV or RV using the acceleration sensor by localizing regions of late onset of motion relative to the QRS, or isovolumic contraction, or mitral valve closure, or by pacing of target regions and measuring LV function in response to pacing. Systems further provide an implantable or non-implantable acceleration sensor device for measuring LV motion and characterizing LV function. An implantable myocardial acceleration sensing system (“IAD”) includes at least one acceleration sensor, a data acquisition and processing device, and an electromagnetic, e.g., RF, communication device. The IAD may be integrated into the pacing lead of a CRT device and can operate independently of the CRT IPG.
54 Citations
9 Claims
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1. A device for monitoring cardiac function, comprising:
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a. a single multi-axis acceleration sensor configured for disposition within the coronary sinus; b. wherein the acceleration sensor is configured to characterize left ventricular function by simultaneously monitoring both cardiac vibration corresponding to mitral regurgitation and left ventricular longitudinal displacement motion; c. a circuit implemented in hardware or software, or both, for receiving signals indicative of left ventricular function including signals corresponding to cardiac vibration caused by mitral regurgitation and signals corresponding to left ventricular longitudinal displacement motion, the circuit further mathematically singly integrating the received signals to obtain velocity information about left ventricular function and the circuit further mathematically doubly integrating the received signals to obtain displacement information about left ventricular function, wherein the single and double integrations are performed using only data from the single multi-axis acceleration sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A device for monitoring cardiac function, comprising:
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a. a catheter including a single three-axis acceleration sensor for disposition within the coronary sinus, wherein the acceleration sensor is configured to characterize left ventricular function by simultaneously monitoring both cardiac vibration corresponding to mitral regurgitation and left ventricular longitudinal displacement motion; b. a guide wire lumen formed within the catheter; and c. a circuit implemented in hardware or software, or both, for receiving signals indicative of left ventricular function including signals corresponding to cardiac vibration caused by mitral regurgitation and signals corresponding to left ventricular longitudinal displacement motion, the circuit further mathematically singly integrating the received signals to obtain velocity information about left ventricular function and the circuit further mathematically doubly integrating the received signals to obtain displacement information about left ventricular function, wherein the single and double integrations are performed using only data from the single multi-axis acceleration sensor, d. such that said device is configured to identify LV pacing regions.
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9. A device for monitoring cardiac function, comprising:
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a. a catheter including a single three-axis acceleration sensor for disposition within the coronary sinus, wherein the acceleration sensor is configured to characterize left ventricular function by simultaneously monitoring both cardiac vibration corresponding to mitral regurgitation and left ventricular longitudinal displacement motion; and b. a circuit implemented in hardware or software, or both, for receiving signals indicative of left ventricular function including signals corresponding to cardiac vibration caused by mitral regurgitation and signals corresponding to left ventricular longitudinal displacement motion, the circuit further mathematically singly integrating the received signals to obtain velocity information about left ventricular function and the circuit further mathematically doubly integrating the received signals to obtain displacement information about left ventricular function, wherein the single and double integrations are performed using only data from the single multi-axis acceleration sensor, c. such that said device is configured to measure motion to characterize LV function.
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Specification